Papain and Calcium drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Papain (papain) and Calcium (calcium). Common drug interactions include back pain among females and prostatitis among males.

The phase IV clinical study analyzes what interactions people have when they take Papain and Calcium. It is created by eHealthMe based on reports of 30 people who take the same drugs from the FDA, and is updated regularly.

What is Papain?

Papain has active ingredients of papain. eHealthMe is studying from 127 Papain users. Check the latest studies of Papain.

What is Calcium?

Calcium has active ingredients of calcium. It is often used in osteoporosis. eHealthMe is studying from 184,203 Calcium users. Check the latest studies of Calcium.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 23, 2026

30 people who take Papain and Calcium together, and have interactions are studied.

What are the common drug interactions of Papain and Calcium, by gender? *:

female:

Back pain
Abdominal discomfort
Neck injury
Road traffic accident
Decreased immune responsiveness
Erythema (redness of the skin)
Neck pain
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
Duodenal ulcer perforation (untreated ulcer can burn through the wall of the stomach)
Gastroenteritis (inflammation of stomach and intestine)

male:

Prostatitis (inflammation of the prostate gland)
Cough
Nerve compression
Pneumonia
Surgery

What are the common drug interactions of Papain and Calcium, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Abdominal discomfort
Duodenal ulcer perforation (untreated ulcer can burn through the wall of the stomach)
Gastroenteritis (inflammation of stomach and intestine)
Anxiety
Dizziness
Face injury
Fall
Fatigue (feeling of tiredness)
Ligament sprain (ligament stretched)
Loss of consciousness

50-59:

n/a

60+:

Asthma
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Neck pain
Prostatitis (inflammation of the prostate gland)
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
Cough
Fungal infection
Infusion site erythema (reddening of the skin at infusion site)
Nerve compression
Burning sensation

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 8 people, 26.67%
Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 5 people, 16.67%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 5 people, 16.67%
Joint Pain: 5 people, 16.67%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 5 people, 16.67%
Combined Immunodeficiency: 4 people, 13.33%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 3 people, 10.00%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 2 people, 6.67%
Ovarian Epithelial Cancer (cancer that begins in the cells on the surface of the ovary): 2 people, 6.67%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 2 people, 6.67%

* Approximation only. Some reports may have incomplete information.

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