Paracetamol and Amitiza drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Paracetamol (acetaminophen) and Amitiza (lubiprostone). Common drug interactions include skin discolouration among females and abdominal distension among males.

The phase IV clinical study analyzes what interactions people have when they take Paracetamol and Amitiza. It is created by eHealthMe based on reports of 35 people who take the same drugs from the FDA, and is updated regularly.

What is Paracetamol?

Paracetamol has active ingredients of acetaminophen. It is often used in pain. eHealthMe is studying from 115,650 Paracetamol users. Check the latest studies of Paracetamol.

What is Amitiza?

Amitiza has active ingredients of lubiprostone. It is often used in constipation. eHealthMe is studying from 10,567 Amitiza users. Check the latest studies of Amitiza.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 04, 2026

35 people who take Paracetamol and Amitiza together, and have interactions are studied.

Paracetamol and Amitiza drug interactions.

What are the common drug interactions of Paracetamol and Amitiza, by gender? *:

female:

Skin discolouration (change of skin colour)
Skin exfoliation (removal of the oldest dead skin cells)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Spinal disorder (disease of spine a back bone)
Stress fracture (fracture of a bone caused by repeated (rather than sudden) mechanical stress)
Swelling face
Therapeutic response decreased (less preventive response)
Therapeutic response unexpected
Urine output decreased
Drug ineffective

male:

Abdominal distension
Back pain
Decreased appetite
Faeces pale
Fatigue (feeling of tiredness)
Feeding disorder (when children refuse to eat certain food groups)
General physical health deterioration (weak health status)
Infection
Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)
Liver disorder (liver diseases)

What are the common drug interactions of Paracetamol and Amitiza, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Anaphylactic reaction (serious allergic reaction)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Chest discomfort
Chest pain
Chronic kidney disease
Diarrhoea
Drug hypersensitivity
Drug intolerance (drug sensitivity)
Dyspepsia (indigestion)
Exfoliative rash (scaly red generalized skin rash)

50-59:

Cerebral palsy
Fall
Feeding disorder (when children refuse to eat certain food groups)
Femur fracture
Gait disturbance
Lung disorder (lung disease)
Pain in extremity
Stress fracture (fracture of a bone caused by repeated (rather than sudden) mechanical stress)
Vomiting

60+:

Abdominal distension
Back pain
Alanine aminotransferase increased
Aspartate aminotransferase increased
Asthenia (weakness)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Blood bilirubin increased
Bone pain
Chills (felling of cold)
Contusion (a type of hematoma of tissue in which capillaries)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 7 people, 20.00%
Hyperkalemia (damage to or disease of the kidney): 5 people, 14.29%
High Blood Pressure: 3 people, 8.57%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 3 people, 8.57%
Stress And Anxiety: 2 people, 5.71%
Sleep Disorder: 2 people, 5.71%
Myelodysplastic Syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged): 2 people, 5.71%
Muscle Spasticity (tight or stiff muscles and an inability to control those muscles): 2 people, 5.71%
Multiple Myeloma (cancer of the plasma cells): 2 people, 5.71%
High Blood Cholesterol: 2 people, 5.71%

* Approximation only. Some reports may have incomplete information.

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