Paracetamol and Cotrim d.s. drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Paracetamol (acetaminophen) and Cotrim d.s. (sulfamethoxazole; trimethoprim). Common drug interactions include pancytopenia among females and hypertensive nephropathy among males.

The phase IV clinical study analyzes what interactions people have when they take Paracetamol and Cotrim d.s.. It is created by eHealthMe based on reports of 20 people who take the same drugs from the FDA, and is updated regularly.

What is Paracetamol?

Paracetamol has active ingredients of acetaminophen. It is often used in pain. eHealthMe is studying from 115,650 Paracetamol users. Check the latest studies of Paracetamol.

What is Cotrim d.s.?

Cotrim d.s. has active ingredients of sulfamethoxazole; trimethoprim. eHealthMe is studying from 274 Cotrim d.s. users. Check the latest studies of Cotrim d.s..

On Jul, 06, 2026

20 people who take Paracetamol and Cotrim d.s. together, and have interactions are studied.

Paracetamol and Cotrim d.s. drug interactions.

What are the common drug interactions of Paracetamol and Cotrim D.S., by gender? *:

female:

Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Leukopenia (less number of white blood cells in blood)
Sepsis (a severe blood infection that can lead to organ failure and death)
Basal cell carcinoma (a skin cancer, it rarely metastasizes or kills)
Chest pain
General physical health deterioration (weak health status)
Infection
Macular oedema (fluid and protein deposits collect on or under the macula of the eye (a yellow central area of the retina) and causes it to thicken)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Neutropenia (an abnormally low number of neutrophils)

male:

Hypertensive nephropathy (hypertensive renal disease)
Febrile neutropenia (fever with reduced white blood cells)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Cough
Diarrhoea
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
General physical health deterioration (weak health status)
Hyperbilirubinaemia (excess of bilirubin in the blood)
Hypotension (abnormally low blood pressure)

What are the common drug interactions of Paracetamol and Cotrim D.S., by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Back pain
Plasma cell myeloma (cancer that begins in plasma cells)

50-59:

Pneumonia
Septic shock (shock due to blood infection)
Bronchopneumonia (inflammation of the lungs, arising in the bronchi or bronchioles)
Bronchospasm (spasm of bronchial smooth muscle producing narrowing of the bronchi)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Cough
Diarrhoea
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Febrile neutropenia (fever with reduced white blood cells)

60+:

Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Sepsis (a severe blood infection that can lead to organ failure and death)
Febrile neutropenia (fever with reduced white blood cells)
Infection
Infusion related reaction
Macular oedema (fluid and protein deposits collect on or under the macula of the eye (a yellow central area of the retina) and causes it to thicken)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Neutropenia (an abnormally low number of neutrophils)
Pericardial effusion (fluid around the heart)
Pleural effusion (water on the lungs)

What are the existing conditions these people have? *

Chronic Lymphocytic Leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell)): 9 people, 45.00%
High Blood Pressure: 5 people, 25.00%
Multiple Myeloma (cancer of the plasma cells): 5 people, 25.00%
Muscle Spasms (muscle contraction): 3 people, 15.00%
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 3 people, 15.00%
Nausea (feeling of having an urge to vomit): 3 people, 15.00%
Oedema (fluid collection in tissue): 2 people, 10.00%
Cough: 2 people, 10.00%
Herpes Zoster: 2 people, 10.00%
Type 2 Diabetes: 2 people, 10.00%

* Approximation only. Some reports may have incomplete information.

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