Paracetamol and Viagra drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Paracetamol (acetaminophen) and Viagra (sildenafil citrate). Common drug interactions include local swelling among females and pneumonia aspiration among males.

The phase IV clinical study analyzes what interactions people have when they take Paracetamol and Viagra. It is created by eHealthMe based on reports of 50 people who take the same drugs from the FDA, and is updated regularly.

What is Paracetamol?

Paracetamol has active ingredients of acetaminophen. It is often used in pain. eHealthMe is studying from 115,650 Paracetamol users. Check the latest studies of Paracetamol.

What is Viagra?

Viagra has active ingredients of sildenafil citrate. It is often used in erection problems. eHealthMe is studying from 63,865 Viagra users. Check the latest studies of Viagra.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

50 people who take Paracetamol and Viagra together, and have interactions are studied.

Paracetamol and Viagra drug interactions.

What are the common drug interactions of Paracetamol and Viagra, by gender? *:

female:

Local swelling (swelling at the site of some application of substance or injury)
Muscular weakness (muscle weakness)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Oedema peripheral (superficial swelling)
Pain in extremity
Pain of skin
Peau d'orange (orange peel skin)
Pruritus (severe itching of the skin)
Rash

male:

Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Anxiety
Nasopharyngitis (inflammation of the nasopharynx)
Pruritus (severe itching of the skin)
Respiratory failure (inadequate gas exchange by the respiratory system)
Blood pressure decreased
Body temperature decreased
Disturbance in attention
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Heart rate increased

What are the common drug interactions of Paracetamol and Viagra, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Anxiety
Chest pain
Dyspnoea (difficult or laboured respiration)
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Contusion (a type of hematoma of tissue in which capillaries)

30-39:

Erythema multiforme (a type of hypersensitivity reaction)
Abdominal pain upper
Lipase increased
Phonophobia (a morbid fear of sounds including your own voice)
Photophobia (extreme sensitivity to light)
Vomiting
Urinary tract infection
Overdose
Pancreatitis acute (sudden inflammation of pancreas)

40-49:

Oedema peripheral (superficial swelling)
Pain in extremity
Pain of skin
Peau d'orange (orange peel skin)
Pruritus (severe itching of the skin)
Rash
Rash macular (small, flat red spots)
Renal failure (kidney dysfunction)
Scar
Skin fibrosis (fibrous tissue formation on skin)

50-59:

Sepsis (a severe blood infection that can lead to organ failure and death)
Erysipelas (bacterial skin infection)
Skin infection
Alanine aminotransferase increased
Anaemia (lack of blood)
Arthralgia (joint pain)
Aspartate aminotransferase increased
Cellulitis (infection under the skin)
Cough
Dermatitis acneiform (dermatoses including acne vulgaris, rosacea, folliculitis, and perioral dermatitis)

60+:

Blood pressure increased
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Cardiac disorder
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Chronic kidney disease
Constipation
Cough
Diastolic dysfunction
Drug ineffective
Duodenitis (inflammation of the duodenum)

What are the existing conditions these people have? *

High Blood Pressure: 7 people, 14.00%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 6 people, 12.00%
Malignant Melanoma (skin cancer rises from melancytes): 6 people, 12.00%
Fever: 6 people, 12.00%
Depression: 5 people, 10.00%
Primary Progressive Multiple Sclerosis (primary progressive inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 4 people, 8.00%
Diarrhea: 4 people, 8.00%
Constipation: 4 people, 8.00%
Stress And Anxiety: 3 people, 6.00%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 3 people, 6.00%

* Approximation only. Some reports may have incomplete information.

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