Pataday and Depakote drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Pataday (olopatadine hydrochloride) and Depakote (divalproex sodium). Common drug interactions include hypomagnesaemia among females and adverse event among males.

The phase IV clinical study analyzes what interactions people have when they take Pataday and Depakote. It is created by eHealthMe based on reports of 38 people who take the same drugs from the FDA, and is updated regularly.

What is Pataday?

Pataday has active ingredients of olopatadine hydrochloride. It is often used in allergies. eHealthMe is studying from 8,288 Pataday users. Check the latest studies of Pataday.

What is Depakote?

Depakote has active ingredients of divalproex sodium. It is often used in bipolar disorder. eHealthMe is studying from 55,581 Depakote users. Check the latest studies of Depakote.

On Jul, 17, 2026

38 people who take Pataday and Depakote together, and have interactions are studied.

What are the common drug interactions of Pataday and Depakote, by gender? *:

female:

Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood)
Hypomania (a mild form of mania, marked by elation and hyperactivity)
Hypotension (abnormally low blood pressure)
Infusion site haemorrhage (bleeding from infusion site)
Injection site bruising
Injection site extravasation (flow of (blood or lymph) from injection site)
Injection site nerve damage
Injection site pain
Injection site rash
Intervertebral disc protrusion (spinal disc protrusion)

male:

Adverse event
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Eye inflammation
Eye pruritus (eye itching)
Fatigue (feeling of tiredness)
Foot fracture
Hypersomnia (excessive daytime sleepiness (eds))
Hypophagia (reduced food intake)
Impaired driving ability
Malaise (a feeling of general discomfort or uneasiness)

What are the common drug interactions of Pataday and Depakote, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Arthralgia (joint pain)
Asthenia (weakness)
Asthma
Cardiac disorder
Cerebral venous thrombosis (clot in brains venous blood system)
Corneal degeneration (abnormal deposition of substances in the transparent front part of the eye)
Dizziness
Dysstasia (difficulty in standing)
Extrasystoles
Fatigue (feeling of tiredness)

20-29:

n/a

30-39:

n/a

40-49:

Renal impairment (severely reduced kidney function)
Restlessness (not able to rest)
Tachyphrenia (abnormally rapid mental activity)
Therapeutic response decreased (less preventive response)
Chronic kidney disease
Dehydration (dryness resulting from the removal of water)
Dizziness
Anxiety
Erythrasma (skin disease that causes brown, scaly skin patches)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)

50-59:

Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Cough
Gingival pain (gum pain)
Glycosylated haemoglobin increased
Tooth infection
Depression
Mood swings (an extreme or rapid change in mood)
Escherichia urinary tract infection (urinary tract infection by escherichia coli)
Activities of daily living impaired
Anaemia (lack of blood)

60+:

Body height decreased
Weight increased
Headache (pain in head)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Constipation
Overdose

What are the existing conditions these people have? *

Asthma: 12 people, 31.58%
High Blood Cholesterol: 10 people, 26.32%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 8 people, 21.05%
Pain: 8 people, 21.05%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 7 people, 18.42%
Migraine (headache): 6 people, 15.79%
Nausea (feeling of having an urge to vomit): 6 people, 15.79%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 6 people, 15.79%
Constipation: 6 people, 15.79%
Seasonal Allergy (allergic condition due to certain season): 5 people, 13.16%

* Approximation only. Some reports may have incomplete information.

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