Flexeril and Clonidine hydrochloride drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Flexeril (cyclobenzaprine hydrochloride) and Clonidine hydrochloride (clonidine hydrochloride). Common drug interactions include malaise among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Flexeril and Clonidine hydrochloride. It is created by eHealthMe based on reports of 26 people who take the same drugs from the FDA, and is updated regularly.

What is Flexeril?

Flexeril has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms. eHealthMe is studying from 38,308 Flexeril users. Check the latest studies of Flexeril.

What is Clonidine hydrochloride?

Clonidine hydrochloride has active ingredients of clonidine hydrochloride. It is often used in high blood pressure. eHealthMe is studying from 5,643 Clonidine hydrochloride users. Check the latest studies of Clonidine hydrochloride.

On Jul, 17, 2026

26 people who take Flexeril and Clonidine hydrochloride together, and have interactions are studied.

Flexeril and Clonidine hydrochloride drug interactions.

What are the common drug interactions of Flexeril and Clonidine Hydrochloride, by gender? *:

female:

Malaise (a feeling of general discomfort or uneasiness)
Asthma
Blood pressure fluctuation
Depression
Pneumonia
Renal failure (kidney dysfunction)
Nausea (feeling of having an urge to vomit)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Fibromyalgia (a long-term condition which causes pain all over the body)
Gait disturbance

male:

Chronic kidney disease
Renal failure (kidney dysfunction)
Constipation
Death
Diarrhoea
Gastrointestinal infection (infection of stomach and intestine)
Hypercholesterolaemia (high levels of cholesterol in the blood)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Cardiovascular disorder (heart diseases)
Fall

What are the common drug interactions of Flexeril and Clonidine Hydrochloride, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Asthma
Blood pressure fluctuation
Depression
Fibromyalgia (a long-term condition which causes pain all over the body)
Gait disturbance
Intervertebral disc degeneration (spinal disc degeneration)
Malaise (a feeling of general discomfort or uneasiness)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Nausea (feeling of having an urge to vomit)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)

40-49:

Hunger
Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings)
Self-injurious ideation
Suicidal ideation
Suicide attempt

50-59:

Blood glucose increased
Anxiety
Arthralgia (joint pain)
Asthma
Balance disorder
Bladder disorder
Blood glucose decreased
Blood pressure fluctuation
Blood sodium decreased
Bone disorder

60+:

Chronic kidney disease
Renal failure (kidney dysfunction)
Abscess (pus)
Abscess limb (limb infection)
Anaphylactic reaction (serious allergic reaction)
Constipation
Death
Dyslipidaemia (abnormal amount of lipids)
Essential hypertension (primary hypertension)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 9 people, 34.62%
Cardiac Disorder: 7 people, 26.92%
Pain: 7 people, 26.92%
Gastric Ulcer (stomach ulcer): 6 people, 23.08%
Blood Pressure Abnormal: 5 people, 19.23%
Gout (uric acid crystals building up in the body): 5 people, 19.23%
Peripheral Swelling: 4 people, 15.38%
Headache (pain in head): 4 people, 15.38%
High Blood Cholesterol: 4 people, 15.38%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 4 people, 15.38%

* Approximation only. Some reports may have incomplete information.

Do you take Flexeril and Clonidine hydrochloride?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously