Paxil and Butrans drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Paxil (paroxetine hydrochloride) and Butrans (buprenorphine). Common drug interactions include cervical myelopathy among females and nausea among males.

The phase IV clinical study analyzes what interactions people have when they take Paxil and Butrans. It is created by eHealthMe based on reports of 45 people who take the same drugs from the FDA, and is updated regularly.

What is Paxil?

Paxil has active ingredients of paroxetine hydrochloride. It is often used in depression. eHealthMe is studying from 92,547 Paxil users. Check the latest studies of Paxil.

What is Butrans?

Butrans has active ingredients of buprenorphine. It is often used in pain. eHealthMe is studying from 64,148 Butrans users. Check the latest studies of Butrans.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

45 people who take Paxil and Butrans together, and have interactions are studied.

What are the common drug interactions of Paxil and Butrans, by gender? *:

female:

Cervical myelopathy (clinical syndrome characterized by clumsiness in hands; gait imbalance; caused by compression of the spinal cord)
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Coronary artery bypass
Diplopia (double vision)
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Drug dependence
Drug effect decreased
Drug effect delayed
Enuresis (repeated inability to control urination)

male:

Nausea (feeling of having an urge to vomit)
Malaise (a feeling of general discomfort or uneasiness)
Back pain
Bipolar disorder (mood disorder)
Blood pressure diastolic increased
Candidiasis (candidiasis or thrush is a fungal infection)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)

What are the common drug interactions of Paxil and Butrans, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Bedridden
Pruritus (severe itching of the skin)
Rash
Somnolence (a state of near-sleep, a strong desire for sleep)

30-39:

Heart rate increased
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Sleep terror (felling of terror in sleep)
Suicidal ideation

40-49:

Speech disorder
Migraine (headache)
Drug ineffective
Hypersomnia (excessive daytime sleepiness (eds))
Nerve injury
Headache (pain in head)
Insomnia (sleeplessness)
Alcohol use
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Asthenia (weakness)

50-59:

Suicide attempt
Spinal osteoarthritis (joint cartilage loss in spine)
Anaemia (lack of blood)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Back disorder
Back pain
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Eyelid oedema (eyelids are swollen and contain excessive fluid)
Gait disturbance
Gastrointestinal viral infection (virus infection of gastrointestinal tract)

60+:

Drug hypersensitivity
Malaise (a feeling of general discomfort or uneasiness)
Bipolar disorder (mood disorder)
Blood pressure diastolic increased
Candidiasis (candidiasis or thrush is a fungal infection)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Dizziness

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 19 people, 42.22%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 12 people, 26.67%
Back Pain: 7 people, 15.56%
Hypersensitivity: 4 people, 8.89%
Muscle Spasms (muscle contraction): 3 people, 6.67%
Migraine (headache): 3 people, 6.67%

* Approximation only. Some reports may have incomplete information.

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