Paxil and Entresto drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Paxil (paroxetine hydrochloride) and Entresto (sacubitril; valsartan). Common drug interactions include syncope among females and hypotension among males.

The phase IV clinical study analyzes what interactions people have when they take Paxil and Entresto. It is created by eHealthMe based on reports of 54 people who take the same drugs from the FDA, and is updated regularly.

What is Paxil?

Paxil has active ingredients of paroxetine hydrochloride. It is often used in depression. eHealthMe is studying from 92,546 Paxil users. Check the latest studies of Paxil.

What is Entresto?

Entresto has active ingredients of sacubitril; valsartan. eHealthMe is studying from 126,628 Entresto users. Check the latest studies of Entresto.

On Jul, 10, 2026

54 people who take Paxil and Entresto together, and have interactions are studied.

What are the common drug interactions of Paxil and Entresto, by gender? *:

female:

Syncope (loss of consciousness with an inability to maintain postural tone)
Therapeutic response decreased (less preventive response)
Mouth ulceration (mouth ulcers)
Oral pain
Skin disorder (skin disease)
Blood potassium decreased
Breast atrophy (overly enlarged breasts)
Cardiac disorder
Cervical vertebral fracture
Chills (felling of cold)

male:

Hypotension (abnormally low blood pressure)
Fatigue (feeling of tiredness)
Dyspnoea exertional (breathlessness or shortness of breath)
Hyperhidrosis (abnormally increased sweating)
Nephropathy (damage to or disease of a kidney)
Nervousness
Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
Red blood cell count decreased
Sluggishness (lacking alertness)
Visual impairment

What are the common drug interactions of Paxil and Entresto, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Septic shock (shock due to blood infection)
Subcutaneous abscess
Urinary tract infection
Wound abscess (pus in wound)
Acute respiratory failure
Chronic respiratory failure
Genital infection
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Cellulitis (infection under the skin)
Cellulitis gangrenous (localized inflammation of the soft or connective tissue with considerable mass of body tissue dies (necrosis))

40-49:

Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Arrhythmia (irregular heartbeat)
Chronic kidney disease
Dizziness
Headache (pain in head)
Hypotension (abnormally low blood pressure)
Malaise (a feeling of general discomfort or uneasiness)
Renal failure (kidney dysfunction)
Renal impairment (severely reduced kidney function)
Road traffic accident

50-59:

Fall

60+:

Hypotension (abnormally low blood pressure)
Fatigue (feeling of tiredness)
Dyspnoea exertional (breathlessness or shortness of breath)
Hyperhidrosis (abnormally increased sweating)
Nephropathy (damage to or disease of a kidney)
Nervousness
Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
Red blood cell count decreased
Sluggishness (lacking alertness)
Visual impairment

What are the existing conditions these people have? *

Cardiac Failure: 11 people, 20.37%
High Blood Cholesterol: 7 people, 12.96%
Pain: 7 people, 12.96%
Diabetes: 7 people, 12.96%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 11.11%
Stress And Anxiety: 6 people, 11.11%
Hypokalemia (low potassium): 5 people, 9.26%
Hyperlipidaemia (presence of excess lipids in the blood): 4 people, 7.41%
Cardiac Failure Congestive: 4 people, 7.41%
Gout (uric acid crystals building up in the body): 4 people, 7.41%

* Approximation only. Some reports may have incomplete information.

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