Paxil and Rapaflo drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Paxil (paroxetine hydrochloride) and Rapaflo (silodosin). Common drug interactions include dyspnoea among males.

The phase IV clinical study analyzes what interactions people have when they take Paxil and Rapaflo. It is created by eHealthMe based on reports of 24 people who take the same drugs from the FDA, and is updated regularly.

What is Paxil?

Paxil has active ingredients of paroxetine hydrochloride. It is often used in depression. eHealthMe is studying from 92,546 Paxil users. Check the latest studies of Paxil.

What is Rapaflo?

Rapaflo has active ingredients of silodosin. It is often used in prostate examination abnormal. eHealthMe is studying from 3,929 Rapaflo users. Check the latest studies of Rapaflo.



On Jul, 27, 2026

24 people who take Paxil and Rapaflo together, and have interactions are studied.

Paxil and Rapaflo drug interactions.

What are the common drug interactions of Paxil and Rapaflo, by gender? *:

female:

n/a

male:

  1. Dyspnoea (difficult or laboured respiration)
  2. Cellulitis (infection under the skin)
  3. Vomiting
  4. Dyskinesia (abnormality or impairment of voluntary movement)
  5. Acute respiratory failure
  6. Agitation (state of anxiety or nervous excitement)
  7. Arthralgia (joint pain)
  8. Back pain
  9. Balance disorder
  10. Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)

What are the common drug interactions of Paxil and Rapaflo, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

  1. Irritability
  2. Rhinorrhoea (watery mucus discharge from the nose)

60+:

  1. Dyspnoea (difficult or laboured respiration)
  2. Fall
  3. Asthenia (weakness)
  4. Back pain
  5. Balance disorder
  6. Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
  7. Blood glucose decreased
  8. Blood pressure decreased
  9. Bradykinesia (decreased bodily movement. it is associated with basal ganglia diseases)
  10. Cardiac failure congestive

What are the existing conditions these people have? *

  1. Parkinson's Disease: 4 people, 16.67%
  2. Stress And Anxiety: 2 people, 8.33%
  3. Sleep Disorder: 2 people, 8.33%
  4. Prostatomegaly (enlargement of the prostate): 2 people, 8.33%
  5. Prostate Cancer: 2 people, 8.33%
  6. Pain: 2 people, 8.33%
  7. Hypotension (abnormally low blood pressure): 2 people, 8.33%
  8. High Blood Cholesterol: 2 people, 8.33%
  9. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 8.33%
  10. Dry Eyes (lack of adequate tears): 2 people, 8.33%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Paxil and Rapaflo:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Paxil:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Rapaflo:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Paxil and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Rapaflo and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on paroxetine hydrochloride and silodosin (the active ingredients of Paxil and Rapaflo, respectively), and Paxil and Rapaflo (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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