Paxil and Rapamune drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Paxil (paroxetine hydrochloride) and Rapamune (sirolimus). Common drug interactions include diabetes mellitus among females and foot ulcer among males.

The phase IV clinical study analyzes what interactions people have when they take Paxil and Rapamune. It is created by eHealthMe based on reports of 48 people who take the same drugs from the FDA, and is updated regularly.

What is Paxil?

Paxil has active ingredients of paroxetine hydrochloride. It is often used in depression. eHealthMe is studying from 92,546 Paxil users. Check the latest studies of Paxil.

What is Rapamune?

Rapamune has active ingredients of sirolimus. It is often used in kidney transplant. eHealthMe is studying from 13,848 Rapamune users. Check the latest studies of Rapamune.

On Jul, 13, 2026

48 people who take Paxil and Rapamune together, and have interactions are studied.

What are the common drug interactions of Paxil and Rapamune, by gender? *:

female:

Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Discomfort
General physical health deterioration (weak health status)
Hypoaesthesia (reduced sense of touch or sensation)
Joint range of motion decreased (disease of joint movement)
Ligament disorder (disease of ligament)
Ligament pain
Mobility decreased (ability to move is reduced)
Muscular weakness (muscle weakness)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)

male:

Foot ulcer
Small intestinal obstruction (blockage in small intestine)
Impaired healing
Osteomyelitis (infection of bone)
Pancreatic disorder
Abscess (pus)
Cardiac disorder
Peripancreatic fluid collection
Abdominal pain
Blood potassium increased

What are the common drug interactions of Paxil and Rapamune, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Seizure cluster (small group of seizure)

30-39:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Arthralgia (joint pain)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Bone pain
Burning sensation
Deformity (disfigurement)
General physical health deterioration (weak health status)
Hypoaesthesia (reduced sense of touch or sensation)
Joint range of motion decreased (disease of joint movement)
Ligament disorder (disease of ligament)

40-49:

White blood cell count increased
Alanine aminotransferase increased
Blood bicarbonate increased
Blood chloride decreased
Blood phosphorus decreased
Blood sodium decreased
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Hepatic cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue)
Hepatitis c
Leukopenia (less number of white blood cells in blood)

50-59:

Renal failure acute (rapid kidney dysfunction)
Renal impairment (severely reduced kidney function)
Renal tubular necrosis (death of kidney tubules)
Road traffic accident
Sepsis (a severe blood infection that can lead to organ failure and death)
Seroma (a tumour like collection of serum in the tissues)
Staphylococcal infection (an infection with staphylococcus bacteria)
Swelling
Tenderness (pain or discomfort when an affected area is touched)
Urinary tract disorder

60+:

Blood potassium increased
Blood sodium decreased
Pancreatic carcinoma (pancreatic cancer)
Pancreatic disorder
Blood albumin increased
Blood alkaline phosphatase increased
Blood bicarbonate decreased
Blood bilirubin increased
Blood glucose increased
Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body)

What are the existing conditions these people have? *

Post-Traumatic Stress Disorder: 4 people, 8.33%
Pain: 3 people, 6.25%
Nausea And Vomiting: 3 people, 6.25%
Hyperglycemia (high blood sugar): 3 people, 6.25%
Diabetes: 3 people, 6.25%

* Approximation only. Some reports may have incomplete information.

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