Paxlovid and Methocarbamol drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Paxlovid (nirmatrelvir; ritonavir) and Methocarbamol (methocarbamol). Common drug interactions include confusional state among females and acute myeloid leukaemia among males.

The phase IV clinical study analyzes what interactions people have when they take Paxlovid and Methocarbamol. It is created by eHealthMe based on reports of 28 people who take the same drugs from the FDA, and is updated regularly.

What is Paxlovid?

Paxlovid has active ingredients of nirmatrelvir; ritonavir. eHealthMe is studying from 38,421 Paxlovid users. Check the latest studies of Paxlovid.

What is Methocarbamol?

Methocarbamol has active ingredients of methocarbamol. It is often used in muscle spasms. eHealthMe is studying from 17,766 Methocarbamol users. Check the latest studies of Methocarbamol.

On Jul, 13, 2026

28 people who take Paxlovid and Methocarbamol together, and have interactions are studied.

Paxlovid and Methocarbamol drug interactions.

What are the common drug interactions of Paxlovid and Methocarbamol, by gender? *:

female:

Confusional state
Decreased appetite
Diarrhoea
Disease recurrence
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Cellulitis (infection under the skin)
Dysgeusia (disorder of the sense of taste)
Faeces discoloured
Hospitalisation
Nausea (feeling of having an urge to vomit)

male:

Acute myeloid leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts)
Arthralgia (joint pain)
Myelodysplastic syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged)
Oropharyngeal pain
Orthostatic hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up)
Rhinorrhoea (watery mucus discharge from the nose)
Urine output increased
White blood cell count increased
Dysgeusia (disorder of the sense of taste)
Fatigue (feeling of tiredness)

What are the common drug interactions of Paxlovid and Methocarbamol, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Cellulitis (infection under the skin)
Disease recurrence
Retching (strong involuntary effort to vomit)
Rotator cuff repair
Sleep disorder
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Dysgeusia (disorder of the sense of taste)
Ear discomfort
Urine output increased

50-59:

Confusional state
Decreased appetite
Diarrhoea
Faeces discoloured
Nausea (feeling of having an urge to vomit)
Blood glucose increased
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Cough
Disease recurrence
Dizziness

60+:

Hospitalisation
Arthralgia (joint pain)
Orthostatic hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up)
Rebound effect (take-back effect)
Rhinorrhoea (watery mucus discharge from the nose)
Urticaria (rash of round, red welts on the skin that itch intensely)
White blood cell count increased
Disease recurrence
Dysgeusia (disorder of the sense of taste)
Femur fracture

What are the existing conditions these people have? *

Pain: 6 people, 21.43%
Diabetes: 5 people, 17.86%
Migraine (headache): 4 people, 14.29%
High Blood Cholesterol: 4 people, 14.29%
Sleep Disorder: 4 people, 14.29%
Hypersensitivity: 4 people, 14.29%
Depression: 4 people, 14.29%
Back Pain: 3 people, 10.71%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 10.71%
Neuralgia (pain in one or more nerves): 3 people, 10.71%

* Approximation only. Some reports may have incomplete information.

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