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Paxlovid and Prempro drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Paxlovid (nirmatrelvir; ritonavir) and Prempro (estrogens, conjugated; medroxyprogesterone acetate). Common drug interactions include disease recurrence among females.

The phase IV clinical study analyzes what interactions people have when they take Paxlovid and Prempro. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Paxlovid?

Paxlovid has active ingredients of nirmatrelvir; ritonavir. eHealthMe is studying from 38,421 Paxlovid users. Check the latest studies of Paxlovid.

What is Prempro?

Prempro has active ingredients of estrogens, conjugated; medroxyprogesterone acetate. It is often used in menopause. eHealthMe is studying from 42,950 Prempro users. Check the latest studies of Prempro.

On Jul, 29, 2026

11 people who take Paxlovid and Prempro together, and have interactions are studied.

Paxlovid and Prempro drug interactions.

What are the common drug interactions of Paxlovid and Prempro, by gender? *:

female:

  1. Disease recurrence
  2. Dysgeusia (disorder of the sense of taste)
  3. Suicide attempt
  4. Vomiting
  5. Diarrhoea
  6. Fatigue (feeling of tiredness)
  7. Headache (pain in head)
  8. Infection
  9. Nausea (feeling of having an urge to vomit)
  10. Pyrexia (fever)

male:

n/a

What are the common drug interactions of Paxlovid and Prempro, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

  1. Rhinorrhoea (watery mucus discharge from the nose)
  2. Suicidal ideation
  3. Suicide attempt
  4. Disease recurrence
  5. Fatigue (feeling of tiredness)
  6. Headache (pain in head)
  7. Pyrexia (fever)

60+:

  1. Disease recurrence
  2. Dysgeusia (disorder of the sense of taste)
  3. Diarrhoea
  4. Infection
  5. Nausea (feeling of having an urge to vomit)
  6. Vomiting

What are the existing conditions these people have? *

  1. Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 1 person, 9.09%
  2. Sleep Disorder: 1 person, 9.09%
  3. Osteoarthritis (a joint disease caused by cartilage loss in a joint): 1 person, 9.09%
  4. Menopausal Symptoms: 1 person, 9.09%
  5. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 9.09%
  6. Dermatitis Atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder): 1 person, 9.09%
  7. Depression: 1 person, 9.09%
  8. Affective Disorder (mental disorder): 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Paxlovid and Prempro?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Paxlovid and Prempro:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Paxlovid:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Prempro:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Paxlovid and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Prempro and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on nirmatrelvir; ritonavir and estrogens, conjugated; medroxyprogesterone acetate (the active ingredients of Paxlovid and Prempro, respectively), and Paxlovid and Prempro (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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