1. Home
  2. Analysis
  3. Penicillin
  4. Hydrocodone

Penicillin and Hydrocodone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Penicillin (penicillin g potassium) and Hydrocodone (hydrocodone bitartrate; ibuprofen). Common drug interactions include pneumonia among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Penicillin and Hydrocodone. It is created by eHealthMe based on reports of 60 people who take the same drugs from the FDA, and is updated regularly.

What is Penicillin?

Penicillin has active ingredients of penicillin g potassium. It is often used in strep throat. eHealthMe is studying from 8,567 Penicillin users. Check the latest studies of Penicillin.

What is Hydrocodone?

Hydrocodone has active ingredients of hydrocodone bitartrate; ibuprofen. eHealthMe is studying from 13,115 Hydrocodone users. Check the latest studies of Hydrocodone.

On Aug, 09, 2026

60 people who take Penicillin and Hydrocodone together, and have interactions are studied.

Penicillin and Hydrocodone drug interactions.

What are the common drug interactions of Penicillin and Hydrocodone, by gender? *:

female:

  1. Pneumonia
  2. Quality of life decreased
  3. Rash
  4. Respiratory tract infection
  5. Rhinorrhoea (watery mucus discharge from the nose)
  6. Scratch
  7. Seizure (abnormal excessive or synchronous neuronal activity in the brain)
  8. Skin burning sensation
  9. Skin exfoliation (removal of the oldest dead skin cells)
  10. Thermal burn (burn by heat)

male:

  1. Chronic kidney disease
  2. Renal failure (kidney dysfunction)
  3. Mobility decreased (ability to move is reduced)
  4. Nephrogenic anaemia (anaemia due to kidney disease)
  5. Renal impairment (severely reduced kidney function)
  6. Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
  7. Compression fracture (fracture due to pressure caused by injury)
  8. Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
  9. Osteoporosis (bones weak and more likely to break)
  10. Death

What are the common drug interactions of Penicillin and Hydrocodone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

  1. Abdominal pain upper

10-19:

n/a

20-29:

  1. Diarrhoea
  2. Gastric disorder (disease of stomach)
  3. Hyperhidrosis (abnormally increased sweating)
  4. Vomiting

30-39:

  1. Chronic kidney disease
  2. Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
  3. Nephrogenic anaemia (anaemia due to kidney disease)
  4. Renal failure (kidney dysfunction)

40-49:

  1. Chronic kidney disease
  2. Renal failure (kidney dysfunction)
  3. Renal injury (kidney injury)
  4. Renal tubular necrosis (death of kidney tubules)
  5. Death
  6. Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
  7. Gastric cancer (stomach cancer)
  8. Scrotal abscess (pus in scrotum)
  9. Sepsis (a severe blood infection that can lead to organ failure and death)
  10. Soft tissue necrosis (death of soft tissue)

50-59:

  1. Scratch
  2. Urticaria (rash of round, red welts on the skin that itch intensely)
  3. Wound infection
  4. Chronic kidney disease
  5. Renal failure (kidney dysfunction)
  6. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  7. Anxiety
  8. Emotional distress
  9. Pain
  10. Bone density decreased

60+:

  1. Chronic kidney disease
  2. Renal failure (kidney dysfunction)
  3. Pain
  4. Renal impairment (severely reduced kidney function)
  5. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  6. Anxiety
  7. Blepharospasm (any abnormal contraction or twitch of the eyelid)
  8. Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
  9. Blood creatinine increased
  10. Bone loss

What are the existing conditions these people have? *

  1. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 39 people, 65.00%
  2. Pain: 33 people, 55.00%
  3. Infection: 24 people, 40.00%
  4. High Blood Pressure: 23 people, 38.33%
  5. High Blood Cholesterol: 23 people, 38.33%
  6. Inflammation: 16 people, 26.67%
  7. Depression: 15 people, 25.00%
  8. Stress And Anxiety: 14 people, 23.33%
  9. Diabetes: 12 people, 20.00%
  10. Hiv Infection: 12 people, 20.00%

* Approximation only. Some reports may have incomplete information.

Do you take Penicillin and Hydrocodone?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Penicillin and Hydrocodone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Penicillin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Hydrocodone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Penicillin and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Hydrocodone and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on penicillin g potassium and hydrocodone bitartrate; ibuprofen (the active ingredients of Penicillin and Hydrocodone, respectively), and Penicillin and Hydrocodone (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

Recent studies on eHealthMe:

© 2026 eHealthMe.com. All rights reserved. Use of this site constitutes acceptance of eHealthMe.com's terms of service and privacy policy.