Spiriva and Akineton drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Spiriva (tiotropium bromide monohydrate) and Akineton (biperiden hydrochloride). Common drug interactions include pneumonia among females and vomiting among males.

The phase IV clinical study analyzes what interactions people have when they take Spiriva and Akineton. It is created by eHealthMe based on reports of 19 people who take the same drugs from the FDA, and is updated regularly.

What is Spiriva?

Spiriva has active ingredients of tiotropium bromide monohydrate. It is often used in chronic obstructive pulmonary disease. eHealthMe is studying from 156,666 Spiriva users. Check the latest studies of Spiriva.

What is Akineton?

Akineton has active ingredients of biperiden hydrochloride. It is often used in parkinson's disease. eHealthMe is studying from 6,140 Akineton users. Check the latest studies of Akineton.

On Aug, 09, 2026

19 people who take Spiriva and Akineton together, and have interactions are studied.

What are the common drug interactions of Spiriva and Akineton, by gender? *:

female:

Pneumonia
Cardiac arrest
Cystitis (inflammation of the wall of the bladder)
Device related infection
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Multi-organ failure (multisystem organ failure)
Oedema peripheral (superficial swelling)
Skin infection
Syncope (loss of consciousness with an inability to maintain postural tone)
Tendon injury

male:

Vomiting
Death
Blood pressure fluctuation
Hyperhidrosis (abnormally increased sweating)
Ileus paralytic (obstruction of the intestine due to paralysis of the intestinal muscles)
Leukocytosis (increased white blood cells)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Neuroleptic malignant syndrome (a life-threatening neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic agents)
Pyrexia (fever)
Respiratory failure (inadequate gas exchange by the respiratory system)

What are the common drug interactions of Spiriva and Akineton, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Blood pressure fluctuation
Hyperhidrosis (abnormally increased sweating)
Leukocytosis (increased white blood cells)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Neuroleptic malignant syndrome (a life-threatening neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic agents)
Oedema peripheral (superficial swelling)
Pneumonia
Pyrexia (fever)
Respiratory failure (inadequate gas exchange by the respiratory system)
Skin infection

60+:

Vomiting
Death
Pneumonia
Psoriasis (immune-mediated disease that affects the skin)
Syncope (loss of consciousness with an inability to maintain postural tone)
Tendon injury
Cardiac arrest
Cystitis (inflammation of the wall of the bladder)
Device related infection
Drug intolerance (drug sensitivity)

What are the existing conditions these people have? *

Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 3 people, 15.79%
Schizophrenia, Paranoid Type (delusions and auditory hallucinations but relatively normal intellectual functioning and expression of affect): 1 person, 5.26%
Insomnia (sleeplessness): 1 person, 5.26%
High Blood Pressure: 1 person, 5.26%
Dyspnea (difficult or laboured breathing): 1 person, 5.26%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 1 person, 5.26%
Cardiac Murmur (an heart sound in valve abnormality): 1 person, 5.26%
Cardiac Failure: 1 person, 5.26%
Akathisia (a movement disorder characterized by a feeling of inner restlessness): 1 person, 5.26%
Adverse Drug Reaction: 1 person, 5.26%

* Approximation only. Some reports may have incomplete information.

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