Penicillin and Lactulose drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Penicillin (penicillin g potassium) and Lactulose (lactulose). Common drug interactions include hypertension among females and alanine aminotransferase increased among males.

The phase IV clinical study analyzes what interactions people have when they take Penicillin and Lactulose. It is created by eHealthMe based on reports of 49 people who take the same drugs from the FDA, and is updated regularly.

What is Penicillin?

Penicillin has active ingredients of penicillin g potassium. It is often used in strep throat. eHealthMe is studying from 8,567 Penicillin users. Check the latest studies of Penicillin.

What is Lactulose?

Lactulose has active ingredients of lactulose. It is often used in constipation. eHealthMe is studying from 46,960 Lactulose users. Check the latest studies of Lactulose.



On Jul, 21, 2026

49 people who take Penicillin and Lactulose together, and have interactions are studied.

Penicillin and Lactulose drug interactions.

What are the common drug interactions of Penicillin and Lactulose, by gender? *:

female:

  1. Hypertension (high blood pressure)
  2. Hypophosphataemia (electrolyte disturbance in which there is an abnormally low level of phosphate in the blood)
  3. Kidney infection
  4. Localised infection (infection at the single location)
  5. Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
  6. Myoclonus (a brief, involuntary twitching of a muscle or a group of muscles)
  7. Oxygen saturation decreased
  8. Pain
  9. Parkinson's disease
  10. Psoriatic arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop)

male:

  1. Alanine aminotransferase increased
  2. Blood alkaline phosphatase increased
  3. Pelvic abscess
  4. Perirectal abscess
  5. Rectal abscess (pus in rectum)
  6. Gastric cancer (stomach cancer)
  7. Umbilical hernia (an outward bulging (protrusion) of the abdominal lining or part of the abdominal organ(s) through the area around the belly button)
  8. Abdominal pain
  9. Arthritis (form of joint disorder that involves inflammation of one or more joints)
  10. Back pain

What are the common drug interactions of Penicillin and Lactulose, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

  1. Umbilical hernia (an outward bulging (protrusion) of the abdominal lining or part of the abdominal organ(s) through the area around the belly button)

20-29:

  1. Abdominal distension
  2. Breast pain
  3. Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
  4. Decreased appetite
  5. Emotional distress
  6. Headache (pain in head)
  7. Myoclonus (a brief, involuntary twitching of a muscle or a group of muscles)
  8. Parkinson's disease
  9. Vaginal discharge

30-39:

  1. Gastritis (inflammation of stomach)
  2. Pain
  3. Chronic kidney disease
  4. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  5. Anxiety
  6. Dyspepsia (indigestion)
  7. Emotional distress

40-49:

  1. Gastric cancer (stomach cancer)
  2. Abdominal pain
  3. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  4. Anxiety
  5. Arthritis (form of joint disorder that involves inflammation of one or more joints)
  6. Back pain
  7. Bipolar disorder (mood disorder)
  8. Emotional distress
  9. Gallbladder disorder
  10. General physical health deterioration (weak health status)

50-59:

  1. Chronic kidney disease
  2. Renal failure (kidney dysfunction)
  3. Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
  4. Pelvic abscess
  5. Perirectal abscess
  6. Rectal abscess (pus in rectum)
  7. Renal tubular necrosis (death of kidney tubules)
  8. Breast pain
  9. Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
  10. Hypophosphataemia (electrolyte disturbance in which there is an abnormally low level of phosphate in the blood)

60+:

  1. Alanine aminotransferase increased
  2. Chronic kidney disease
  3. Asthenia (weakness)
  4. Bronchitis chronic (inflammation of the mucous membrane in the bronchial tubes- chronic)
  5. Depressed level of consciousness
  6. Dyspnoea (difficult or laboured respiration)
  7. Encephalopathy (functioning of the brain is affected by some agent or condition)
  8. Fatigue (feeling of tiredness)
  9. Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
  10. Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)

What are the existing conditions these people have? *

  1. Pain: 20 people, 40.82%
  2. Infection: 17 people, 34.69%
  3. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 15 people, 30.61%
  4. Diabetes: 10 people, 20.41%
  5. High Blood Pressure: 9 people, 18.37%
  6. Indigestion: 9 people, 18.37%
  7. High Blood Cholesterol: 8 people, 16.33%
  8. Dyslipidaemia (abnormal amount of lipids): 8 people, 16.33%
  9. Wound Necrosis (damaged cell of wound): 7 people, 14.29%
  10. Wound Infection: 6 people, 12.24%

* Approximation only. Some reports may have incomplete information.

Do you take Penicillin and Lactulose?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Penicillin and Lactulose:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Penicillin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Lactulose:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Penicillin and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Lactulose and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on penicillin g potassium and lactulose (the active ingredients of Penicillin and Lactulose, respectively), and Penicillin and Lactulose (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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