Pennsaid and Levaquin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Pennsaid (diclofenac sodium) and Levaquin (levofloxacin). Common drug interactions include chronic kidney disease among females and renal failure among males.

The phase IV clinical study analyzes what interactions people have when they take Pennsaid and Levaquin. It is created by eHealthMe based on reports of 17 people who take the same drugs from the FDA, and is updated regularly.

What is Pennsaid?

Pennsaid has active ingredients of diclofenac sodium. eHealthMe is studying from 2,849 Pennsaid users. Check the latest studies of Pennsaid.

What is Levaquin?

Levaquin has active ingredients of levofloxacin. It is often used in sinusitis. eHealthMe is studying from 56,638 Levaquin users. Check the latest studies of Levaquin.

On Jul, 18, 2026

17 people who take Pennsaid and Levaquin together, and have interactions are studied.

Pennsaid and Levaquin drug interactions.

What are the common drug interactions of Pennsaid and Levaquin, by gender? *:

female:

Chronic kidney disease
Renal failure (kidney dysfunction)
Acute respiratory failure
Gastric ulcer (stomach ulcer)
Hypoxia (low oxygen in tissues)
Sepsis (a severe blood infection that can lead to organ failure and death)
Suicidal ideation
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Acute coronary syndrome (acute chest pain and other symptoms that happen because the heart does not get blood)
Acute left ventricular failure (heart attack)

male:

Renal failure (kidney dysfunction)
Abdominal pain
Dehydration (dryness resulting from the removal of water)
Dyspepsia (indigestion)
Fall
Finger deformity (a deformed position of the finger)
Foetal exposure during pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect)
Gait disturbance
Hip fracture
Hiv infection

What are the common drug interactions of Pennsaid and Levaquin, by age (0-1 to 60+)? *:

0-1:

Acquired immunodeficiency syndrome (disease of the human immune system caused by the human immunodeficiency virus (hiv))
Arthralgia (joint pain)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cardiac disorder
Critical illness polyneuropathy
Decreased immune responsiveness
Fall
Finger deformity (a deformed position of the finger)
Foetal exposure during pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect)
Gait disturbance

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Abdominal pain
Decreased appetite
Dehydration (dryness resulting from the removal of water)
Dyspepsia (indigestion)
Small intestinal obstruction (blockage in small intestine)

40-49:

Chronic kidney disease
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure (kidney dysfunction)

50-59:

Alanine aminotransferase increased
Arthrodesis
Aspartate aminotransferase increased
Bone deformity
Burning sensation
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
Cyst (a closed sac)
Drug ineffective
Energy increased
Fatigue (feeling of tiredness)

60+:

Acute respiratory failure
Chronic kidney disease
Hypoxia (low oxygen in tissues)
Renal failure (kidney dysfunction)
Sepsis (a severe blood infection that can lead to organ failure and death)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 13 people, 76.47%
Pain: 12 people, 70.59%
Asthma: 10 people, 58.82%
Stress And Anxiety: 9 people, 52.94%
Depression: 8 people, 47.06%
Fibromyalgia (a long-term condition which causes pain all over the body): 8 people, 47.06%
Irritable Bowel Syndrome: 7 people, 41.18%
High Blood Cholesterol: 7 people, 41.18%
High Blood Pressure: 6 people, 35.29%
Gastric Ulcer (stomach ulcer): 6 people, 35.29%

* Approximation only. Some reports may have incomplete information.

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