Pentam and Hydroxyzine hydrochloride drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Pentam (pentamidine isethionate) and Hydroxyzine hydrochloride (hydroxyzine hydrochloride). Common drug interactions include cystic fibrosis among females and chronic graft versus host disease among males.

The phase IV clinical study analyzes what interactions people have when they take Pentam and Hydroxyzine hydrochloride. It is created by eHealthMe based on reports of 32 people who take the same drugs from the FDA, and is updated regularly.

What is Pentam?

Pentam has active ingredients of pentamidine isethionate. eHealthMe is studying from 5,686 Pentam users. Check the latest studies of Pentam.

What is Hydroxyzine hydrochloride?

Hydroxyzine hydrochloride has active ingredients of hydroxyzine hydrochloride. It is often used in stress and anxiety. eHealthMe is studying from 10,486 Hydroxyzine hydrochloride users. Check the latest studies of Hydroxyzine hydrochloride.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

32 people who take Pentam and Hydroxyzine hydrochloride together, and have interactions are studied.

Pentam and Hydroxyzine hydrochloride drug interactions.

What are the common drug interactions of Pentam and Hydroxyzine Hydrochloride, by gender? *:

female:

Cystic fibrosis (disease of the secretary glands)
Depressed mood
Distal intestinal obstruction syndrome (blockage of the intestines by thickened stool and occurs in individuals with cystic fibrosis)
Drug-induced liver injury (diseases of the liver that are caused by physician-prescribed medications)
Duodenal ulcer
Dyspnoea (difficult or laboured respiration)
Encephalopathy (functioning of the brain is affected by some agent or condition)
Fatigue (feeling of tiredness)
Sinus disorder (disease of sinus)
Activated partial thromboplastin time prolonged

male:

Chronic graft versus host disease (immune cells attack the host's body cells after transplant)
Pyrexia (fever)
Hypertension (high blood pressure)
Hypertriglyceridaemia (excess of triglycerides in the blood)
Obliterative bronchiolitis (bronchiolar inflammation)
Septic shock (shock due to blood infection)
Stomatitis (inflammation of mucous membrane of mouth)
Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))
Haemoglobin decreased
Acute graft versus host disease (acute complication following an allogeneic tissue/blood transplant)

What are the common drug interactions of Pentam and Hydroxyzine Hydrochloride, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Cerebral haemorrhage (bleeding within the brain)
Enterococcal sepsis
Haemolytic uraemic syndrome (blood clotting disease caused by e. coli infection, birth control pills, pneumonia, medications, and more)
Infection

10-19:

Acute lymphocytic leukaemia recurrent (cancer in which the bone marrow makes too many lymphocytes-recurrent)
Capillary leak syndrome (capillary leaks plasma)
Chronic graft versus host disease (immune cells attack the host's body cells after transplant)
Cystitis haemorrhagic (blood in the urine and painful voiding)
Diarrhoea
Engraft failure
Gastritis (inflammation of stomach)
Graft versus host disease in intestine (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body and damages intestinal mucosal membrane)
Graft versus host disease in skin (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the skin)
Hypertension (high blood pressure)

20-29:

Chronic graft versus host disease (immune cells attack the host's body cells after transplant)
Cytomegalovirus infection
Liver disorder (liver diseases)
Pyrexia (fever)
Aspergillosis (an infection caused by a fungus called aspergillus)
Bacterial infection
Candidiasis (candidiasis or thrush is a fungal infection)
Meningitis (inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges)
Pneumonia
Viral infection

30-39:

Dizziness
Nausea (feeling of having an urge to vomit)
Acute graft versus host disease (acute complication following an allogeneic tissue/blood transplant)
Abdominal pain
Ascites (accumulation of fluid in the abdominal cavity)
Blood creatinine increased
Cough
Cystic fibrosis (disease of the secretary glands)
Dehydration (dryness resulting from the removal of water)
Depressed mood

40-49:

Febrile neutropenia (fever with reduced white blood cells)
Activated partial thromboplastin time prolonged
Agitation (state of anxiety or nervous excitement)
Alanine aminotransferase increased
Alveolitis allergic (inflammation of the alveoli within the lung caused by hypersensitivity to inhaled organic dusts)
Aspartate aminotransferase increased
Asthenia (weakness)
Autoimmune disorder (a condition in which the immune system attacks the body's normal substances and tissue)
Autoimmune hepatitis
Blood bilirubin increased

50-59:

Diarrhoea
Liver disorder (liver diseases)
Leukopenia (less number of white blood cells in blood)
Nausea (feeling of having an urge to vomit)
Pyrexia (fever)
Stomatitis (inflammation of mucous membrane of mouth)
Thrombocytopenia (decrease of platelets in blood)
Vomiting
Back pain
Dyspnoea (difficult or laboured respiration)

60+:

n/a

What are the existing conditions these people have? *

Nausea (feeling of having an urge to vomit): 8 people, 25.00%
Acute Lymphocytic Leukemia (All) (cancer of the white blood cells characterized by excess lymphoblasts): 7 people, 21.88%
Bone Marrow Conditioning Regimen: 7 people, 21.88%
Thrombocytopenia (decrease of platelets in blood): 6 people, 18.75%
Stomatitis (inflammation of mucous membrane of mouth): 6 people, 18.75%
Oedema (fluid collection in tissue): 6 people, 18.75%
Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood): 6 people, 18.75%
Hiv Infection: 6 people, 18.75%
Aplastic Anemia: 5 people, 15.62%
Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 4 people, 12.50%

* Approximation only. Some reports may have incomplete information.

Do you take Pentam and Hydroxyzine hydrochloride?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously