Pentam and Temozolomide drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Pentam (pentamidine isethionate) and Temozolomide (temozolomide). Common drug interactions include neutrophil count decreased among females and deep vein thrombosis among males.

The phase IV clinical study analyzes what interactions people have when they take Pentam and Temozolomide. It is created by eHealthMe based on reports of 29 people who take the same drugs from the FDA, and is updated regularly.

What is Pentam?

Pentam has active ingredients of pentamidine isethionate. eHealthMe is studying from 5,686 Pentam users. Check the latest studies of Pentam.

What is Temozolomide?

Temozolomide has active ingredients of temozolomide. It is often used in glioblastoma multiforme. eHealthMe is studying from 16,644 Temozolomide users. Check the latest studies of Temozolomide.

On Aug, 08, 2026

29 people who take Pentam and Temozolomide together, and have interactions are studied.

Pentam and Temozolomide drug interactions.

What are the common drug interactions of Pentam and Temozolomide, by gender? *:

female:

Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
Platelet count decreased
Lymphopenia (an abnormally low level of lymphocytes in the blood)
Acute respiratory failure
Asthenia (weakness)
Blood sodium decreased
Death
Drug ineffective
Dry skin
Failure to thrive (inadequate weight gain and physical growth in children)

male:

Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Pyrexia (fever)
Radiation necrosis (death of cell due to radiation)
Sepsis (a severe blood infection that can lead to organ failure and death)
Colitis ulcerative (inflammation of colon with ulcer)
Diarrhoea
Fall
Gout (uric acid crystals building up in the body)
Hypoglycaemia (deficiency of glucose in the bloodstream)
Pulmonary embolism (blockage of the main artery of the lung)

What are the common drug interactions of Pentam and Temozolomide, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Diarrhoea
Febrile neutropenia (fever with reduced white blood cells)
Thrombocytopenia (decrease of platelets in blood)
Vomiting
Malignant neoplasm progression (cancer tumour came back)

10-19:

Urinary tract infection staphylococcal
Urine sodium decreased
Thrombocytopenia (decrease of platelets in blood)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Febrile neutropenia (fever with reduced white blood cells)
Intracranial pressure increased (high pressure inside the skull and thus in the brain tissue and cerebrospinal fluid)
Diarrhoea
Mucosal inflammation (infection of mucous membrane)
Pyrexia (fever)
Renal tubular disorder (disease of kidney tubules)

20-29:

n/a

30-39:

Acute respiratory failure
Drug ineffective
Pneumothorax (the presence of air or gas in the cavity between the lungs and the chest wall, causing collapse of the lung)
Septic shock (shock due to blood infection)

40-49:

Cytomegalovirus infection
Drug ineffective

50-59:

Pyrexia (fever)
Gait disturbance
Hepatitis (inflammation of the liver)
Hypotension (abnormally low blood pressure)
Pancreatitis acute (sudden inflammation of pancreas)
Radiation necrosis (death of cell due to radiation)
Sepsis (a severe blood infection that can lead to organ failure and death)
Colitis ulcerative (inflammation of colon with ulcer)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Fall

60+:

Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
Platelet count decreased
Neutropenia (an abnormally low number of neutrophils)
Thrombocytopenia (decrease of platelets in blood)
Asthenia (weakness)
Death
Failure to thrive (inadequate weight gain and physical growth in children)
Lymphopenia (an abnormally low level of lymphocytes in the blood)

What are the existing conditions these people have? *

Brain Neoplasm Malignant (brain cancer tumour): 3 people, 10.34%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 2 people, 6.90%
Non-Hodgkin's Lymphoma (malignant (cancer) cells form in the lymph system): 2 people, 6.90%
Medulloblastoma (a fast-growing, high-grade tumour that always begins in the cerebellum): 2 people, 6.90%
Headache (pain in head): 2 people, 6.90%
Gliosarcoma (a cancer of the brain that comes from glial, or supportive, brain cells): 2 people, 6.90%
Glioblastoma (most common and most aggressive malignant primary brain tumour in humans): 2 people, 6.90%

* Approximation only. Some reports may have incomplete information.

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