Pepcid and Apixaban drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Pepcid (famotidine) and Apixaban (apixaban). Common drug interactions include haematochezia among females and pyrexia among males.

The phase IV clinical study analyzes what interactions people have when they take Pepcid and Apixaban. It is created by eHealthMe based on reports of 87 people who take the same drugs from the FDA, and is updated regularly.

What is Pepcid?

Pepcid has active ingredients of famotidine. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 55,774 Pepcid users. Check the latest studies of Pepcid.

What is Apixaban?

Apixaban has active ingredients of apixaban. It is often used in blood clots. eHealthMe is studying from 60,351 Apixaban users. Check the latest studies of Apixaban.

On Jul, 30, 2026

87 people who take Pepcid and Apixaban together, and have interactions are studied.

What are the common drug interactions of Pepcid and Apixaban, by gender? *:

female:

Haematochezia (passage of stools containing blood)
Nausea (feeling of having an urge to vomit)
Chest pain
Erythema (redness of the skin)
Limb discomfort (discomfort in leg)
Peripheral swelling
Syncope (loss of consciousness with an inability to maintain postural tone)
Alanine aminotransferase increased
Arrhythmia (irregular heartbeat)
Arthralgia (joint pain)

male:

Pyrexia (fever)
Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
Dyspnoea (difficult or laboured respiration)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Corneal abrasion (loss of the surface of cornea)
Rash maculo-papular (red area on the skin that is covered with small confluent bumps)
Fall
Flushing (the warm, red condition of human skin)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Prostate cancer

What are the common drug interactions of Pepcid and Apixaban, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Alanine aminotransferase increased
Aspartate aminotransferase increased
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Sepsis (a severe blood infection that can lead to organ failure and death)

10-19:

n/a

20-29:

n/a

30-39:

Chronic kidney disease
Renal failure (kidney dysfunction)
Abdominal distension
Chest pain
Erythema (redness of the skin)
Influenza
Limb discomfort (discomfort in leg)
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Neck pain
Oxygen saturation decreased

40-49:

Chronic kidney disease
Pulmonary embolism (blockage of the main artery of the lung)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Fall
Muscle rupture (tear in muscle)
Renal failure (kidney dysfunction)
Renal impairment (severely reduced kidney function)
Respiratory failure (inadequate gas exchange by the respiratory system)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)

50-59:

Constipation
Cytomegalovirus test positive
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Embolism (obstruction of an artery, typically by a clot of blood or an air bubble)
Escherichia bacteraemia (presence of bacteria escherichia coli in the blood)
Fatigue (feeling of tiredness)
Hypercholesterolaemia (high levels of cholesterol in the blood)
Malnutrition (a condition that results from eating a diet in which certain nutrients are lacking)
Nephrogenic anaemia (anaemia due to kidney disease)
Neutropenia (an abnormally low number of neutrophils)

60+:

Chronic kidney disease
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Corneal abrasion (loss of the surface of cornea)
Dehydration (dryness resulting from the removal of water)
Rash maculo-papular (red area on the skin that is covered with small confluent bumps)
Fall
Nephropathy (damage to or disease of a kidney)
Renal impairment (severely reduced kidney function)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Haematochezia (passage of stools containing blood)

What are the existing conditions these people have? *

Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 17 people, 19.54%
High Blood Pressure: 14 people, 16.09%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 14 people, 16.09%
Pain: 13 people, 14.94%
Nausea (feeling of having an urge to vomit): 10 people, 11.49%
Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 9 people, 10.34%
High Blood Cholesterol: 8 people, 9.20%
Cough: 8 people, 9.20%
Fluid Retention (an abnormal accumulation of fluid in the blood): 7 people, 8.05%
Bone Marrow Conditioning Regimen: 6 people, 6.90%

* Approximation only. Some reports may have incomplete information.

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