Pepcid and Penlac drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Pepcid (famotidine) and Penlac (ciclopirox). Common drug interactions include abdominal pain among females and cardiac failure congestive among males.

The phase IV clinical study analyzes what interactions people have when they take Pepcid and Penlac. It is created by eHealthMe based on reports of 27 people who take the same drugs from the FDA, and is updated regularly.

What is Pepcid?

Pepcid has active ingredients of famotidine. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 55,775 Pepcid users. Check the latest studies of Pepcid.

What is Penlac?

Penlac has active ingredients of ciclopirox. eHealthMe is studying from 492 Penlac users. Check the latest studies of Penlac.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

27 people who take Pepcid and Penlac together, and have interactions are studied.

What are the common drug interactions of Pepcid and Penlac, by gender? *:

female:

Abdominal pain
Blindness
Confusional state
Eye pain
Head injury
Musculoskeletal discomfort (discomfort in the body's muscles, joints, tendons, ligaments and nerves)
Memory impairment
Alopecia (absence of hair from areas of the body)
Balance disorder
Bradyphrenia (neurological term referring to the slowness of thought common to many disorders of the brain)

male:

Cardiac failure congestive
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Asthenia (weakness)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Azotaemia (excess of urea or other nitrogenous compounds in the blood)
Blood glucose increased
Fluid overload (too much fluid in the blood)
Haematocrit decreased
Loss of consciousness
Malignant hypertension (a hypertensive emergency is a condition in which elevated blood pressure results in target organ damage)

What are the common drug interactions of Pepcid and Penlac, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Chronic kidney disease
Renal injury (kidney injury)

60+:

Pain
Pain in extremity
Neuropathy peripheral (surface nerve damage)
Gait disturbance
Nervousness
Abdominal pain
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Blindness
Confusional state
Dizziness

What are the existing conditions these people have? *

Pain: 14 people, 51.85%
Trigeminal Neuralgia (a painful condition of the nerve responsible for most facial sensation): 13 people, 48.15%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 13 people, 48.15%
Cardiac Disorder: 12 people, 44.44%
Abdominal Pain: 12 people, 44.44%
Restless Leg Syndrome (a powerful urge to move your legs): 12 people, 44.44%
Neuropathy Peripheral (surface nerve damage): 12 people, 44.44%
Nausea (feeling of having an urge to vomit): 12 people, 44.44%
Muscle Spasms (muscle contraction): 12 people, 44.44%
Joint Pain: 12 people, 44.44%

* Approximation only. Some reports may have incomplete information.

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