Percocet and Epiduo drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Percocet (acetaminophen; oxycodone hydrochloride) and Epiduo (adapalene; benzoyl peroxide). Common drug interactions include fibromyalgia among females and abdominal pain among males.

The phase IV clinical study analyzes what interactions people have when they take Percocet and Epiduo. It is created by eHealthMe based on reports of 19 people who take the same drugs from the FDA, and is updated regularly.

What is Percocet?

Percocet has active ingredients of acetaminophen; oxycodone hydrochloride. It is often used in pain. eHealthMe is studying from 119,838 Percocet users. Check the latest studies of Percocet.

What is Epiduo?

Epiduo has active ingredients of adapalene; benzoyl peroxide. It is often used in acne. eHealthMe is studying from 1,581 Epiduo users. Check the latest studies of Epiduo.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 25, 2026

19 people who take Percocet and Epiduo together, and have interactions are studied.

What are the common drug interactions of Percocet and Epiduo, by gender? *:

female:

Fibromyalgia (a long-term condition which causes pain all over the body)
Gait disturbance
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
Haemorrhage (bleeding)
Hepatic adenoma (benign liver tumour)
Human papilloma virus test positive
Hypercoagulation (increased tendency for clotting of the blood)
Insomnia (sleeplessness)
Lyme disease (a bacterial infection that is spread to humans by infected ticks)
Motion sickness (travel sickness)

male:

Abdominal pain
Sedation

What are the common drug interactions of Percocet and Epiduo, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Abdominal pain

20-29:

Drug hypersensitivity
Fibromyalgia (a long-term condition which causes pain all over the body)
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
Hypercoagulation (increased tendency for clotting of the blood)
Neuralgia (pain in one or more nerves)
Suicidal ideation
Post procedural complication
Retching (strong involuntary effort to vomit)
Skin irritation
Therapeutic response unexpected

30-39:

n/a

40-49:

n/a

50-59:

Anxiety
Arthropathy
Motion sickness (travel sickness)
Musculoskeletal chest pain (pain in chest muscle or nerve or bones)
Nail infection
Nausea (feeling of having an urge to vomit)
Onychalgia (nail biting)
Onychomycosis (fungal infection of the nail)
Vomiting
Weight decreased

60+:

n/a

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 13 people, 68.42%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 11 people, 57.89%
Inflammatory Bowel Disease: 3 people, 15.79%
Stress And Anxiety: 2 people, 10.53%
Seborrhoeic Dermatitis (a common, inflammatory skin condition that causes flaky, white to yellowish scales to form on oily areas such as the scalp): 2 people, 10.53%
Seborrheic Dermatitis (a common, inflammatory skin condition that causes flaky, white to yellowish scales to form on oily areas such as the scalp): 2 people, 10.53%
Osteoporosis (bones weak and more likely to break): 2 people, 10.53%
Insomnia (sleeplessness): 2 people, 10.53%
Birth Control: 2 people, 10.53%

* Approximation only. Some reports may have incomplete information.

Do you take Percocet and Epiduo?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously