Percocet and Eylea drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Percocet (acetaminophen; oxycodone hydrochloride) and Eylea (aflibercept). Common drug interactions include gastrointestinal haemorrhage among females and conjunctival haemorrhage among males.

The phase IV clinical study analyzes what interactions people have when they take Percocet and Eylea. It is created by eHealthMe based on reports of 22 people who take the same drugs from the FDA, and is updated regularly.

What is Percocet?

Percocet has active ingredients of acetaminophen; oxycodone hydrochloride. It is often used in pain. eHealthMe is studying from 119,838 Percocet users. Check the latest studies of Percocet.

What is Eylea?

Eylea has active ingredients of aflibercept. It is often used in macular degeneration. eHealthMe is studying from 27,868 Eylea users. Check the latest studies of Eylea.

On Jul, 12, 2026

22 people who take Percocet and Eylea together, and have interactions are studied.

What are the common drug interactions of Percocet and Eylea, by gender? *:

female:

Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Blindness unilateral
Bronchial secretion retention
Eye disorder
Neoplasm malignant (cancer tumour)
Pulmonary mass
Retinal detachment (a disorder of the eye in which the retina peels away from its underlying layer of support tissue)
Retinal haemorrhage (bleeding from retina)
Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))

male:

Conjunctival haemorrhage (bleeding underneath the conjunctiva)
Dry eye (lack of adequate tears)
Photophobia (extreme sensitivity to light)
Vascular rupture
Visual impairment
Vitritis (inflammation of the vitreous humour of the eye)
Eye irritation
Eye pain
Foreign body sensation in eyes (feeling of something in eye)
Punctate keratitis (inflammation of the cornea with tiny spots)

What are the common drug interactions of Percocet and Eylea, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Eye disorder
Visual impairment
Vitritis (inflammation of the vitreous humour of the eye)
Blindness unilateral
Bronchial secretion retention
Neoplasm malignant (cancer tumour)
Pulmonary mass
Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))
Vascular rupture

What are the existing conditions these people have? *

Cardiac Failure Congestive: 8 people, 36.36%
Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 7 people, 31.82%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 7 people, 31.82%
Diabetic Retinal Oedema (excessive build-up of fluid in the retina due to diabetes): 3 people, 13.64%
Retinal Vessel Occlusion (a blockage in one of the small arteries): 2 people, 9.09%
Diabetic Retinopathy (damage to the retina caused by complications of diabetes): 2 people, 9.09%
Age-Related Macular Degeneration: 2 people, 9.09%

* Approximation only. Some reports may have incomplete information.

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