Percocet and Nyquil drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Percocet (acetaminophen; oxycodone hydrochloride) and Nyquil (acetaminophen / dextromethorphan / doxylamine / pseudoephedrine). Common drug interactions include hypertension among females and upper respiratory tract infection among males.

The phase IV clinical study analyzes what interactions people have when they take Percocet and Nyquil. It is created by eHealthMe based on reports of 39 people who take the same drugs from the FDA, and is updated regularly.

What is Percocet?

Percocet has active ingredients of acetaminophen; oxycodone hydrochloride. It is often used in pain. eHealthMe is studying from 119,838 Percocet users. Check the latest studies of Percocet.

What is Nyquil?

Nyquil has active ingredients of acetaminophen / dextromethorphan / doxylamine / pseudoephedrine. It is often used in cold symptoms. eHealthMe is studying from 2,240 Nyquil users. Check the latest studies of Nyquil.

On Aug, 08, 2026

39 people who take Percocet and Nyquil together, and have interactions are studied.

What are the common drug interactions of Percocet and Nyquil, by gender? *:

female:

Hypertension (high blood pressure)
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Irritability
Irritable bowel syndrome
Joint swelling
Limb injury
Loss of employment
Lymphadenopathy (disease or enlargement of lymph nodes)
Mass
Memory impairment

male:

Upper respiratory tract infection
Erythema (redness of the skin)
Sinusitis (inflammation of sinus)
Therapeutic response unexpected
Back injury
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Depression
Drug dependence
Dyspnoea (difficult or laboured respiration)
Gait disturbance

What are the common drug interactions of Percocet and Nyquil, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Choking (mechanical obstruction of the flow of air from the environment into the lungs)
Occipital neuralgia (a condition characterized by chronic pain in the upper neck)
Restless legs syndrome (a powerful urge to move your legs)
Sneezing

20-29:

n/a

30-39:

Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Nausea (feeling of having an urge to vomit)
Obsessive-compulsive disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;)
Oropharyngeal pain
Panic attack
Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur)
Personality disorder
Rhinorrhoea (watery mucus discharge from the nose)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Sexual dysfunction (difficulty experienced by an individual or a couple during any stage of a normal sexual activity)

40-49:

Somnolence (a state of near-sleep, a strong desire for sleep)
Abdominal discomfort
Drug ineffective
Fatigue (feeling of tiredness)
Gastric disorder (disease of stomach)
Haematemesis (vomiting of blood)
Ketoacidosis (high concentrations of ketone bodies in blood)
Malaise (a feeling of general discomfort or uneasiness)
Pyrexia (fever)
Stomatitis (inflammation of mucous membrane of mouth)

50-59:

Death
Diarrhoea

60+:

Death
Erythema (redness of the skin)
Asthenia (weakness)
Balance disorder
Contusion (a type of hematoma of tissue in which capillaries)
Dehydration (dryness resulting from the removal of water)
Depression
Disturbance in attention
Drug hypersensitivity
Dry mouth

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 9 people, 23.08%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 6 people, 15.38%
Back Pain: 4 people, 10.26%
Nasopharyngitis (inflammation of the nasopharynx): 3 people, 7.69%
Insomnia (sleeplessness): 3 people, 7.69%
Weakness: 2 people, 5.13%
Headache (pain in head): 2 people, 5.13%
Arthropathy: 2 people, 5.13%
Asthma: 2 people, 5.13%
Bleeding Disorders: 2 people, 5.13%

* Approximation only. Some reports may have incomplete information.

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