Percocet and Zelboraf drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Percocet (acetaminophen; oxycodone hydrochloride) and Zelboraf (vemurafenib). Common drug interactions include fatigue among females and arthralgia among males.

The phase IV clinical study analyzes what interactions people have when they take Percocet and Zelboraf. It is created by eHealthMe based on reports of 19 people who take the same drugs from the FDA, and is updated regularly.

What is Percocet?

Percocet has active ingredients of acetaminophen; oxycodone hydrochloride. It is often used in pain. eHealthMe is studying from 119,838 Percocet users. Check the latest studies of Percocet.

What is Zelboraf?

Zelboraf has active ingredients of vemurafenib. eHealthMe is studying from 8,392 Zelboraf users. Check the latest studies of Zelboraf.

On Jul, 10, 2026

19 people who take Percocet and Zelboraf together, and have interactions are studied.

Percocet and Zelboraf drug interactions.

What are the common drug interactions of Percocet and Zelboraf, by gender? *:

female:

Fatigue (feeling of tiredness)
Nausea (feeling of having an urge to vomit)
Vomiting
Asthenia (weakness)
Disease progression
Drug intolerance (drug sensitivity)
Local swelling (swelling at the site of some application of substance or injury)
Lymphadenopathy (disease or enlargement of lymph nodes)
Lymphoedema (localized fluid retention and tissue swelling)
Pleural effusion (water on the lungs)

male:

Arthralgia (joint pain)
Fatigue (feeling of tiredness)
Myalgia (muscle pain)
Ageusia (loss of taste functions of the tongue)
Decreased appetite
Dizziness
Mass
Cough
Death
Neoplasm (tumour)

What are the common drug interactions of Percocet and Zelboraf, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Arthralgia (joint pain)
Fatigue (feeling of tiredness)
Headache (pain in head)
Influenza like illness
Myalgia (muscle pain)
Nausea (feeling of having an urge to vomit)
Pain of skin
Sunburn
Vomiting
Dermatitis acneiform (dermatoses including acne vulgaris, rosacea, folliculitis, and perioral dermatitis)

50-59:

Arthralgia (joint pain)
Diarrhoea
Feeling hot
Hot flush (sudden feelings of heat)
Hyperhidrosis (abnormally increased sweating)
Nausea (feeling of having an urge to vomit)
Pruritus (severe itching of the skin)
Pyrexia (fever)
Temperature intolerance (inability to go in temperature)
Vomiting

60+:

Fatigue (feeling of tiredness)
Local swelling (swelling at the site of some application of substance or injury)
Anxiety
Asthenia (weakness)
Death
Decreased appetite
Disease progression
Dizziness
Drug intolerance (drug sensitivity)
Incision site pain

What are the existing conditions these people have? *

Metastatic Malignant Melanoma (spreadable cancer tumour of melanine): 6 people, 31.58%
Malignant Melanoma (skin cancer rises from melancytes): 5 people, 26.32%
Nausea (feeling of having an urge to vomit): 4 people, 21.05%
Stress And Anxiety: 3 people, 15.79%
Multiple Myeloma (cancer of the plasma cells): 2 people, 10.53%
Thyroid Cancer: 1 person, 5.26%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 1 person, 5.26%
Rectal Cancer (cancer of rectum): 1 person, 5.26%
Neoplasm Malignant (cancer tumour): 1 person, 5.26%
Nausea And Vomiting: 1 person, 5.26%

* Approximation only. Some reports may have incomplete information.

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