Percodan and Metformin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Percodan (aspirin; oxycodone hydrochloride; oxycodone terephthalate) and Metformin (metformin hydrochloride). Common drug interactions include abdominal pain among females and pleural effusion among males.

The phase IV clinical study analyzes what interactions people have when they take Percodan and Metformin. It is created by eHealthMe based on reports of 16 people who take the same drugs from the FDA, and is updated regularly.

What is Percodan?

Percodan has active ingredients of aspirin; oxycodone hydrochloride; oxycodone terephthalate. It is often used in pain. eHealthMe is studying from 12,885 Percodan users. Check the latest studies of Percodan.

What is Metformin?

Metformin has active ingredients of metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 465,354 Metformin users. Check the latest studies of Metformin.

On Jul, 16, 2026

16 people who take Percodan and Metformin together, and have interactions are studied.

Percodan and Metformin drug interactions.

What are the common drug interactions of Percodan and Metformin, by gender? *:

female:

Abdominal pain
Abdominal pain upper
Abnormal loss of weight
Chest pain
Cholecystitis chronic (long lasting infection of gallbladder)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Cholesterosis (abnormal deposition of cholesterol in tissues)
Eructation (release of gas from the digestive tract)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Nausea (feeling of having an urge to vomit)

male:

Pleural effusion (water on the lungs)
Malignant pleural effusion (a condition in which cancer causes an abnormal amount of fluid to collect between the thin layers of tissue lining of lung)
Completed suicide (act of taking one's own life)
Constipation
Decreased appetite
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Dehydration (dryness resulting from the removal of water)
Diarrhoea
Dizziness
Enterococcal infection

What are the common drug interactions of Percodan and Metformin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Abdominal pain
Abdominal pain upper
Abnormal loss of weight
Chest pain
Cholecystitis chronic (long lasting infection of gallbladder)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Cholesterosis (abnormal deposition of cholesterol in tissues)
Eructation (release of gas from the digestive tract)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Nausea (feeling of having an urge to vomit)

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

Pleural effusion (water on the lungs)
Malignant pleural effusion (a condition in which cancer causes an abnormal amount of fluid to collect between the thin layers of tissue lining of lung)
Candidiasis (candidiasis or thrush is a fungal infection)
Cardiac valve vegetation (heart valve abnormal growth)
Cholecystitis acute (rapid infection of gallbladder)
Completed suicide (act of taking one's own life)
Constipation
Decreased appetite
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Dehydration (dryness resulting from the removal of water)

What are the existing conditions these people have? *

High Blood Pressure: 8 people, 50.00%
Cardiac Disorder: 7 people, 43.75%
Prostate Cancer Metastatic: 7 people, 43.75%
Metastases To Bone (cancer spreads to bone): 7 people, 43.75%
Joint Pain: 7 people, 43.75%
High Blood Cholesterol: 7 people, 43.75%
Cancer Pain: 7 people, 43.75%
Birth Control: 4 people, 25.00%
Premenstrual Syndrome: 2 people, 12.50%
Acute Myocardial Infarction (acute heart attack): 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

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