Percodan and Methotrexate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Percodan (aspirin; oxycodone hydrochloride; oxycodone terephthalate) and Methotrexate (methotrexate sodium). Common drug interactions include bronchopneumonia among females and fatigue among males.

The phase IV clinical study analyzes what interactions people have when they take Percodan and Methotrexate. It is created by eHealthMe based on reports of 18 people who take the same drugs from the FDA, and is updated regularly.

What is Percodan?

Percodan has active ingredients of aspirin; oxycodone hydrochloride; oxycodone terephthalate. It is often used in pain. eHealthMe is studying from 12,885 Percodan users. Check the latest studies of Percodan.

What is Methotrexate?

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 604,312 Methotrexate users. Check the latest studies of Methotrexate.

On Jul, 15, 2026

18 people who take Percodan and Methotrexate together, and have interactions are studied.

Percodan and Methotrexate drug interactions.

What are the common drug interactions of Percodan and Methotrexate, by gender? *:

female:

Bronchopneumonia (inflammation of the lungs, arising in the bronchi or bronchioles)
Cardiac failure
Respiratory failure (inadequate gas exchange by the respiratory system)
Infection
Ischaemic hepatitis (decreased blood supply to the liver resulting in injury to liver cells)
Candida sepsis (candida in blood stream)
Systemic candida (whole body fungal infection)
Aspergillosis (an infection caused by a fungus called aspergillus)
Injection site pain
Psoriasis (immune-mediated disease that affects the skin)

male:

Fatigue (feeling of tiredness)
Impaired work ability
Dyspnoea exertional (breathlessness or shortness of breath)
Mycobacterium avium complex infection
Nasopharyngitis (inflammation of the nasopharynx)
Oropharyngeal pain
Otitis externa (external ear infection)
Pleural effusion (water on the lungs)
Tuberculosis (a bacterial infection by mycobacterium tuberculosis)
Insomnia (sleeplessness)

What are the common drug interactions of Percodan and Methotrexate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Injection site pain
Psoriasis (immune-mediated disease that affects the skin)
Red blood cell count decreased
White blood cell count decreased
Abdominal pain upper
Cough
Depression
Dyspnoea exertional (breathlessness or shortness of breath)
Fatigue (feeling of tiredness)
Impaired work ability

60+:

Bronchopneumonia (inflammation of the lungs, arising in the bronchi or bronchioles)
Cardiac failure
Bronchopulmonary aspergillosis (lung disorder caused by aspergillus fungi)
Death
Haemodynamic instability (disturbances in the blood movement in our body)
Sepsis (a severe blood infection that can lead to organ failure and death)
Stress cardiomyopathy (stress-induced chronic disease of the heart muscle)
Respiratory failure (inadequate gas exchange by the respiratory system)
Infection
Ischaemic hepatitis (decreased blood supply to the liver resulting in injury to liver cells)

What are the existing conditions these people have? *

Depression: 14 people, 77.78%
Tuberculosis (a bacterial infection by mycobacterium tuberculosis): 12 people, 66.67%
Osteoporosis (bones weak and more likely to break): 12 people, 66.67%
Joint Pain: 12 people, 66.67%
High Blood Cholesterol: 4 people, 22.22%
Hair Loss: 4 people, 22.22%
Ventricular Extrasystoles (premature cardiac contraction): 3 people, 16.67%
Psoriasis (immune-mediated disease that affects the skin): 3 people, 16.67%
Mitral Valve Prolapse (heart's mitral valve doesn't work well): 3 people, 16.67%
Ankylosing Spondylitis (type of arthritis affecting the spine): 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

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