Periactin and Ativan drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Periactin (cyproheptadine hydrochloride) and Ativan (lorazepam). Common drug interactions include adrenal insufficiency among females and ankle fracture among males.

The phase IV clinical study analyzes what interactions people have when they take Periactin and Ativan. It is created by eHealthMe based on reports of 55 people who take the same drugs from the FDA, and is updated regularly.

What is Periactin?

Periactin has active ingredients of cyproheptadine hydrochloride. It is often used in migraine. eHealthMe is studying from 2,214 Periactin users. Check the latest studies of Periactin.

What is Ativan?

Ativan has active ingredients of lorazepam. It is often used in stress and anxiety. eHealthMe is studying from 78,506 Ativan users. Check the latest studies of Ativan.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

55 people who take Periactin and Ativan together, and have interactions are studied.

What are the common drug interactions of Periactin and Ativan, by gender? *:

female:

Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids)
Alcohol withdrawal syndrome
Alcoholism (problems with alcohol)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Arthralgia (joint pain)
Back disorder
Blood pressure systolic increased
Breath sounds
Bundle branch block left (absence of transmission of electric impulses from the atrioventricular (av) bundle of his to the left ventricle)

male:

Ankle fracture
Chronic kidney disease
Renal failure (kidney dysfunction)
Agitation (state of anxiety or nervous excitement)
Alanine aminotransferase increased
Appendicitis (inflammation of the appendix)
Arteriospasm coronary (spasm of the large- or medium-sized coronary arteries)
Blood creatinine increased
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Chest pain

What are the common drug interactions of Periactin and Ativan, by age (0-1 to 60+)? *:

0-1:

Abdominal compartment syndrome (increased pressure in abdomen)
Ascites (accumulation of fluid in the abdominal cavity)
Blood lactic acid increased
Cholecystitis (infection of gallbladder)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Coagulopathy (blood's ability to clot is impaired)
Duodenal perforation (complication of duodenal ulcer)
Enterococcal infection
Fluid retention (an abnormal accumulation of fluid in the blood)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)

2-9:

Pleural effusion (water on the lungs)
Acinetobacter infection (infection by group of bacteria commonly found in soil and water)
Diarrhoea
Diarrhoea haemorrhagic (bloody diarrhoea)
Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
Haematoma (collection of blood outside the blood vessels)
Pyrexia (fever)
Septic shock (shock due to blood infection)
Tooth abscess (pus formation in tooth)
Malignant neoplasm progression (cancer tumour came back)

10-19:

Infusion related reaction
Disease progression
Neoplasm (tumour)
Anaphylactic reaction (serious allergic reaction)
Asthenia (weakness)
Blood creatinine increased
Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
Coagulopathy (blood's ability to clot is impaired)
Confusional state
Decreased appetite

20-29:

Pyrexia (fever)
Type 2 diabetes mellitus
Adverse drug reaction
Agitation (state of anxiety or nervous excitement)
Asthenia (weakness)
Balance disorder
Drooling (drop saliva uncontrollably from the mouth)
Drug ineffective
Drug toxicity
Dysphagia (a condition in which swallowing is difficult or painful)

30-39:

Injection site erythema (redness at injection site)
Injection site pain
Injection site urticaria (rash of round, red welts on the skin at injection site)

40-49:

Decreased appetite
Diarrhoea
Nausea (feeling of having an urge to vomit)
Ankle fracture
Chronic kidney disease
Tibia fracture (fracture of lower leg bone)
Abdominal pain
Abdominal pain lower
Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)

50-59:

Nausea (feeling of having an urge to vomit)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Sweating increased (excess sweating)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Ventricular extrasystoles (premature cardiac contraction)
Ventricular hypertrophy (enlargement of ventricles (lower chambers) in the heart)
Vomiting
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Irritability
Muscle spasticity (tight or stiff muscles and an inability to control those muscles)

60+:

Pain
Death
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Chest discomfort
Constipation
Decreased appetite
Dermatitis acneiform (dermatoses including acne vulgaris, rosacea, folliculitis, and perioral dermatitis)
Disease progression
Drug dependence
Drug effect decreased

What are the existing conditions these people have? *

Pain: 9 people, 16.36%
Depression: 4 people, 7.27%
Cough: 4 people, 7.27%
Neuropathy Peripheral (surface nerve damage): 3 people, 5.45%
Muscle Spasticity (tight or stiff muscles and an inability to control those muscles): 3 people, 5.45%
Itching: 3 people, 5.45%
Insomnia (sleeplessness): 3 people, 5.45%
Inflammatory Bowel Disease: 3 people, 5.45%
Immunodeficiency Disorders: 3 people, 5.45%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 5.45%

* Approximation only. Some reports may have incomplete information.

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