Periactin and Bactrim ds drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Periactin (cyproheptadine hydrochloride) and Bactrim ds (sulfamethoxazole; trimethoprim). Common drug interactions include chronic kidney disease among females and cardiac arrest among males.

The phase IV clinical study analyzes what interactions people have when they take Periactin and Bactrim ds. It is created by eHealthMe based on reports of 16 people who take the same drugs from the FDA, and is updated regularly.

What is Periactin?

Periactin has active ingredients of cyproheptadine hydrochloride. It is often used in migraine. eHealthMe is studying from 2,214 Periactin users. Check the latest studies of Periactin.

What is Bactrim ds?

Bactrim ds has active ingredients of sulfamethoxazole; trimethoprim. It is often used in urinary tract infection. eHealthMe is studying from 17,027 Bactrim ds users. Check the latest studies of Bactrim ds.

On Jul, 06, 2026

16 people who take Periactin and Bactrim ds together, and have interactions are studied.

Periactin and Bactrim ds drug interactions.

What are the common drug interactions of Periactin and Bactrim Ds, by gender? *:

female:

Chronic kidney disease
Dyspepsia (indigestion)
Renal injury (kidney injury)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Renal failure (kidney dysfunction)
Acute left ventricular failure (heart attack)
Lumbar spinal stenosis (a medical condition in which the spinal canal narrows and compresses the spinal cord and nerves at the level of the lumbar bone)
Pyrexia (fever)
Rash
Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve)

male:

Cardiac arrest
Cardiac failure
Malaise (a feeling of general discomfort or uneasiness)
Peroneal nerve palsy
Pharyngeal oedema (abnormal accumulation of fluid in the cavities and intercellular spaces of the pharyngeal)
Post procedural infection
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Sinusitis (inflammation of sinus)
Viral myocarditis (inflammation of heart muscle caused by viral infection)
Hypoglycaemia (deficiency of glucose in the bloodstream)

What are the common drug interactions of Periactin and Bactrim Ds, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Influenza
Malaise (a feeling of general discomfort or uneasiness)
Post procedural infection
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Sinusitis (inflammation of sinus)
Viral myocarditis (inflammation of heart muscle caused by viral infection)

20-29:

Blood creatine phosphokinase increased

30-39:

n/a

40-49:

n/a

50-59:

Chronic kidney disease
Dyspepsia (indigestion)
Renal injury (kidney injury)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Renal failure (kidney dysfunction)

60+:

Cardiac arrest
Cardiac failure
Rash
Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Hypoglycaemia (deficiency of glucose in the bloodstream)
Nausea (feeling of having an urge to vomit)
Acute left ventricular failure (heart attack)
Dysphagia (a condition in which swallowing is difficult or painful)
Dyspnoea (difficult or laboured respiration)

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 31.25%
Cystic Fibrosis (disease of the secretary glands): 4 people, 25.00%
Nausea (feeling of having an urge to vomit): 3 people, 18.75%
Depression: 3 people, 18.75%
Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve): 2 people, 12.50%
Rickets (softening of bones): 2 people, 12.50%
Oedema Peripheral (superficial swelling): 2 people, 12.50%
Back Pain: 2 people, 12.50%
Constipation: 2 people, 12.50%
Multiple Myeloma (cancer of the plasma cells): 2 people, 12.50%

* Approximation only. Some reports may have incomplete information.

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