Periactin and Heparin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Periactin (cyproheptadine hydrochloride) and Heparin (heparin sodium). Common drug interactions include chronic kidney disease among females and nausea among males.

The phase IV clinical study analyzes what interactions people have when they take Periactin and Heparin. It is created by eHealthMe based on reports of 27 people who take the same drugs from the FDA, and is updated regularly.

What is Periactin?

Periactin has active ingredients of cyproheptadine hydrochloride. It is often used in migraine. eHealthMe is studying from 2,214 Periactin users. Check the latest studies of Periactin.

What is Heparin?

Heparin has active ingredients of heparin sodium. It is often used in blood clots. eHealthMe is studying from 92,141 Heparin users. Check the latest studies of Heparin.

On Jul, 26, 2026

27 people who take Periactin and Heparin together, and have interactions are studied.

Periactin and Heparin drug interactions.

What are the common drug interactions of Periactin and Heparin, by gender? *:

female:

Chronic kidney disease
Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
Contusion (a type of hematoma of tissue in which capillaries)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Dysphagia (a condition in which swallowing is difficult or painful)
Haemoglobin decreased
Headache (pain in head)
Hyperhidrosis (abnormally increased sweating)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)

male:

Nausea (feeling of having an urge to vomit)
Pyrexia (fever)
Device related infection
Epistaxis (bleed from the nose)
Factor ix inhibition (suppression of factor ix)
Hypersensitivity
Nephritis (inflammation of the nephrons in the kidneys)
Nephrotic syndrome (kidney disease with proteinuria, hypoalbuminemia, and oedema)
Sepsis (a severe blood infection that can lead to organ failure and death)
Staphylococcal infection (an infection with staphylococcus bacteria)

What are the common drug interactions of Periactin and Heparin, by age (0-1 to 60+)? *:

0-1:

Anaphylactic reaction (serious allergic reaction)
Device related infection
Epistaxis (bleed from the nose)
Factor ix inhibition (suppression of factor ix)
Hypersensitivity
Nephritis (inflammation of the nephrons in the kidneys)
Nephrotic syndrome (kidney disease with proteinuria, hypoalbuminemia, and oedema)
Sepsis (a severe blood infection that can lead to organ failure and death)
Staphylococcal infection (an infection with staphylococcus bacteria)
Air embolism

2-9:

Hypertrichosis (hair growth on the body in an amount considered abnormal)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Impaired gastric emptying
Impetigo (contagious skin infection)
Influenza
Leukocytosis (increased white blood cells)
Lipase increased
Lung disorder (lung disease)
Lung neoplasm (tumour of lung)
Mycoplasma infection (bacterial infection)

10-19:

Abdominal abscess (collection of pus in abdomen)
Anastomotic leak
Ileal stenosis (obstruction in the ileal)
Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
Malaise (a feeling of general discomfort or uneasiness)
Nervous system disorder (a general class of medical conditions affecting the nervous system)
Pain in extremity
Seizure (abnormal excessive or synchronous neuronal activity in the brain)

20-29:

Nausea (feeling of having an urge to vomit)
Aortic thrombosis (formation of a blood clot inside aorta)
Appendicitis (inflammation of the appendix)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Chylothorax (collection of lymph fluid around the lung)
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
Diarrhoea
Gastroenteritis (inflammation of stomach and intestine)
Hypoalbuminaemia (levels of albumin in blood serum are abnormally low)
Infective pulmonary exacerbation of cystic fibrosis (severe infective lung disease with production of abnormally thick mucus)

30-39:

n/a

40-49:

n/a

50-59:

Chronic kidney disease
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure (kidney dysfunction)

60+:

Septic shock (shock due to blood infection)
Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
Headache (pain in head)
Heart rate increased
Hyperhidrosis (abnormally increased sweating)
Hypersensitivity
Leukocytosis (increased white blood cells)
Mouth haemorrhage (bleeding from mouth)
Nausea (feeling of having an urge to vomit)
Organ failure

What are the existing conditions these people have? *

Immune Tolerance Induction: 5 people, 18.52%
Fever: 5 people, 18.52%
Nausea (feeling of having an urge to vomit): 4 people, 14.81%
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters): 3 people, 11.11%
Pain: 2 people, 7.41%
Neoplasm Malignant (cancer tumour): 2 people, 7.41%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 7.41%
Cystic Fibrosis (disease of the secretary glands): 2 people, 7.41%
Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 2 people, 7.41%

* Approximation only. Some reports may have incomplete information.

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