Periactin and Nexium drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Periactin (cyproheptadine hydrochloride) and Nexium (esomeprazole magnesium). Common drug interactions include bronchitis among females and infective pulmonary exacerbation of cystic fibrosis among males.

The phase IV clinical study analyzes what interactions people have when they take Periactin and Nexium. It is created by eHealthMe based on reports of 91 people who take the same drugs from the FDA, and is updated regularly.

What is Periactin?

Periactin has active ingredients of cyproheptadine hydrochloride. It is often used in migraine. eHealthMe is studying from 2,214 Periactin users. Check the latest studies of Periactin.

What is Nexium?

Nexium has active ingredients of esomeprazole magnesium. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 245,678 Nexium users. Check the latest studies of Nexium.

On Jul, 31, 2026

91 people who take Periactin and Nexium together, and have interactions are studied.

What are the common drug interactions of Periactin and Nexium, by gender? *:

female:

Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Death
Nasal polyps (masses that develop in the lining of the nose)
Nephropathy (damage to or disease of a kidney)
Suicidal ideation
Ascites (accumulation of fluid in the abdominal cavity)
Atelectasis (partial or complete collapse of the lung)
Cellulitis (infection under the skin)
Chronic sinusitis (long lasting inflammation of the paranasal sinuses)
Coagulopathy (blood's ability to clot is impaired)

male:

Infective pulmonary exacerbation of cystic fibrosis (severe infective lung disease with production of abnormally thick mucus)
Staphylococcal infection (an infection with staphylococcus bacteria)
Anaemia (lack of blood)
Aspartate aminotransferase increased
Asthenia (weakness)
Fall
Gamma-glutamyltransferase increased
Hospitalisation
Vomiting
Gastric cancer (stomach cancer)

What are the common drug interactions of Periactin and Nexium, by age (0-1 to 60+)? *:

0-1:

Abdominal compartment syndrome (increased pressure in abdomen)
Ascites (accumulation of fluid in the abdominal cavity)
Blood lactic acid increased
Cholecystitis (infection of gallbladder)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Coagulopathy (blood's ability to clot is impaired)
Duodenal perforation (complication of duodenal ulcer)
Enterococcal infection
Fluid retention (an abnormal accumulation of fluid in the blood)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)

2-9:

Staphylococcal infection (an infection with staphylococcus bacteria)
Infective pulmonary exacerbation of cystic fibrosis (severe infective lung disease with production of abnormally thick mucus)
Red man syndrome (a reaction to the drug vancomycin)
Otitis media (inflammation of the middle ear)
Alanine aminotransferase increased
Aspartate aminotransferase increased
Gamma-glutamyltransferase increased
Hepatomegaly (abnormal enlargement of the liver)
Chronic kidney disease
Hepatic enzyme increased

10-19:

Nasal polyps (masses that develop in the lining of the nose)
Atelectasis (partial or complete collapse of the lung)
Chronic sinusitis (long lasting inflammation of the paranasal sinuses)
Infective pulmonary exacerbation of cystic fibrosis (severe infective lung disease with production of abnormally thick mucus)
Pneumonia
Pyrexia (fever)
Coagulopathy (blood's ability to clot is impaired)
Cystic fibrosis (disease of the secretary glands)
Facial pain
Metastases to central nervous system (cancer spreads to central nervous system)

20-29:

Infective pulmonary exacerbation of cystic fibrosis (severe infective lung disease with production of abnormally thick mucus)
Allergy to animal
Gastric fistula (abnormal opening that allows the contents of the stomach or intestines to leak)
Nausea (feeling of having an urge to vomit)
Vomiting
Weight decreased

30-39:

n/a

40-49:

Chronic kidney disease
Death
Nephrogenic anaemia (anaemia due to kidney disease)
Nephropathy (damage to or disease of a kidney)
Renal failure (kidney dysfunction)
Cholecystitis acute (rapid infection of gallbladder)
Drug level increased
Hypokalaemia (low potassium)
Suicidal ideation

50-59:

Blood thyroid stimulating hormone decreased
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Drug ineffective
Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)
Metastases to adrenals (cancer spreads to adrenal gland of kidney)
Metastases to lymph nodes (cancer spreads to lymph node)
Oral candidiasis (fungal infection of mouth)
Pancreatic carcinoma metastatic (pancreatic cancer- metastatic)
Vaginal burning sensation

60+:

Asthenia (weakness)
Anaemia (lack of blood)
Chest pain
Chronic kidney disease
Confusional state
Constipation
Dizziness
Drug toxicity
Drug-induced liver injury (diseases of the liver that are caused by physician-prescribed medications)
Head injury

What are the existing conditions these people have? *

Cystic Fibrosis (disease of the secretary glands): 21 people, 23.08%
Pain: 16 people, 17.58%
Depression: 10 people, 10.99%
High Blood Pressure: 8 people, 8.79%
Cough: 7 people, 7.69%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 6 people, 6.59%
Schizoaffective Disorder (a mental disorder characterized by disordered thought): 5 people, 5.49%
Restless Leg Syndrome (a powerful urge to move your legs): 5 people, 5.49%
Joint Pain: 5 people, 5.49%
Itching: 5 people, 5.49%

* Approximation only. Some reports may have incomplete information.

Do you take Periactin and Nexium?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously