Periactin and Phenergan drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Periactin (cyproheptadine hydrochloride) and Phenergan (promethazine hydrochloride). Common drug interactions include application site urticaria among females and intestinal obstruction among males.

The phase IV clinical study analyzes what interactions people have when they take Periactin and Phenergan. It is created by eHealthMe based on reports of 63 people who take the same drugs from the FDA, and is updated regularly.

What is Periactin?

Periactin has active ingredients of cyproheptadine hydrochloride. It is often used in migraine. eHealthMe is studying from 2,214 Periactin users. Check the latest studies of Periactin.

What is Phenergan?

Phenergan has active ingredients of promethazine hydrochloride. It is often used in nausea. eHealthMe is studying from 25,312 Phenergan users. Check the latest studies of Phenergan.

On Jul, 25, 2026

63 people who take Periactin and Phenergan together, and have interactions are studied.

Periactin and Phenergan drug interactions.

What are the common drug interactions of Periactin and Phenergan, by gender? *:

female:

Application site urticaria
Application site vesicles (small bubble within a cell at application site)
Arterial thrombosis limb (formation of a blood clot inside a blood vessel, obstructing the flow of blood through the circulatory system-limb)
Arthralgia (joint pain)
Ascites (accumulation of fluid in the abdominal cavity)
Back pain
Benign intracranial hypertension (benign intracranial hypertension (bih) is a headache syndrome)
Bile duct obstruction (blockage in the tubes that carry bile from the liver to the gallbladder)
Blood glucose increased
Cellulitis (infection under the skin)

male:

Intestinal obstruction
Neutropenia (an abnormally low number of neutrophils)
Blood glucose increased
Diarrhoea
Drug ineffective
Emphysema (chronic respiratory disease - over inflation of the air sacs (alveoli) in the lungs)
Feeling hot
Haematocrit decreased
Haemoglobin decreased
Hepatic neoplasm malignant (liver cancer)

What are the common drug interactions of Periactin and Phenergan, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Ankle fracture
Arthralgia (joint pain)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
Drug ineffective
Dry skin
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters)
Pain in extremity
Pruritus (severe itching of the skin)
Urinary tract infection

10-19:

Gastrointestinal disorder (functional problems of gastrointestinal tract)
Asthenia (weakness)
Atrioventricular block first degree (heart block first degree)
Diarrhoea
Dysuria (painful or difficult urination)
Fatigue (feeling of tiredness)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Haemoglobin decreased
Menorrhagia (an abnormally heavy bleeding and prolonged menstrual period at regular intervals)
Platelet count decreased

20-29:

Anxiety
Biliary dyskinesia (motility disorder that affects the gallbladder and sphincter of oddi)
Cholecystitis chronic (long lasting infection of gallbladder)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Injury
Pain
Pulmonary embolism (blockage of the main artery of the lung)
Appendicitis (inflammation of the appendix)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Hypoaesthesia (reduced sense of touch or sensation)

30-39:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Application site erythema (redness of the skin at application site)
Application site pain
Application site rash
Application site urticaria
Application site vesicles (small bubble within a cell at application site)
Arterial thrombosis limb (formation of a blood clot inside a blood vessel, obstructing the flow of blood through the circulatory system-limb)
Cholecystitis (infection of gallbladder)
Death

40-49:

Malnutrition (a condition that results from eating a diet in which certain nutrients are lacking)
Pain
Vision blurred
Hallucination (an experience involving the perception of something not present)
Dehydration (dryness resulting from the removal of water)
Depression

50-59:

Intestinal obstruction
Neutropenia (an abnormally low number of neutrophils)
Pleural effusion (water on the lungs)
Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
Death
Diarrhoea
Blood glucose increased
Emphysema (chronic respiratory disease - over inflation of the air sacs (alveoli) in the lungs)
Haematocrit decreased
Haemoglobin decreased

60+:

Hyperhidrosis (abnormally increased sweating)
Abdominal pain
Pharyngeal oedema (abnormal accumulation of fluid in the cavities and intercellular spaces of the pharyngeal)
Shock (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin)
Syncope (loss of consciousness with an inability to maintain postural tone)
Thrombosis (formation of a blood clot inside a blood vessel)
Cardiac disorder
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Dyspnoea (difficult or laboured respiration)
Enterococcal sepsis

What are the existing conditions these people have? *

High Blood Pressure: 7 people, 11.11%
Stress And Anxiety: 6 people, 9.52%
Pain: 6 people, 9.52%
Headache (pain in head): 6 people, 9.52%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 9.52%
Fever: 6 people, 9.52%
Non-Small Cell Lung Cancer Metastatic (type of epithelial lung cancer spreads to other parts): 5 people, 7.94%
Hepatitis C: 5 people, 7.94%
Asthma: 5 people, 7.94%
Depression: 4 people, 6.35%

* Approximation only. Some reports may have incomplete information.

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