Periactin and Zantac drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Periactin (cyproheptadine hydrochloride) and Zantac (ranitidine hydrochloride). Common drug interactions include organ failure among females and cough among males.

The phase IV clinical study analyzes what interactions people have when they take Periactin and Zantac. It is created by eHealthMe based on reports of 79 people who take the same drugs from the FDA, and is updated regularly.

What is Periactin?

Periactin has active ingredients of cyproheptadine hydrochloride. It is often used in migraine. eHealthMe is studying from 2,214 Periactin users. Check the latest studies of Periactin.

What is Zantac?

Zantac has active ingredients of ranitidine hydrochloride. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 434,161 Zantac users. Check the latest studies of Zantac.

On Jul, 17, 2026

79 people who take Periactin and Zantac together, and have interactions are studied.

What are the common drug interactions of Periactin and Zantac, by gender? *:

female:

Organ failure
Overdose
Pruritus (severe itching of the skin)
Vision blurred
Cholecystitis chronic (long lasting infection of gallbladder)
Dehydration (dryness resulting from the removal of water)
Gastroenteritis (inflammation of stomach and intestine)
Pulmonary embolism (blockage of the main artery of the lung)
Abdominal pain
Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)

male:

Cough
Constipation
Vitamin d deficiency
Pain
Renal failure (kidney dysfunction)
Cerebellar ataxia (loss of coordination)
Cerebellar atrophy (degeneration of the section of the brain responsible for balance, voluntary muscle movements)
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Dysarthria (speech disorder)
Fall

What are the common drug interactions of Periactin and Zantac, by age (0-1 to 60+)? *:

0-1:

Acute respiratory failure
Bronchiolitis (inflammation of the membranes lining the bronchioles in lungs)
Coma (state of unconsciousness lasting more than six hours)
Corona virus infection (infection caused by a corona virus)
Drug hypersensitivity
Dyspnoea (difficult or laboured respiration)
Hypoventilation (too shallow or too slow breathing, which does not meet the needs of the body)
Influenza
Pneumonia
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)

2-9:

Diarrhoea
Drug level increased
Heart rate increased
Pyrexia (fever)
Ventricular extrasystoles (premature cardiac contraction)
Viral infection
Weight decreased
Abdominal pain
Back pain
Dehydration (dryness resulting from the removal of water)

10-19:

Infective pulmonary exacerbation of cystic fibrosis (severe infective lung disease with production of abnormally thick mucus)
Nasal polyps (masses that develop in the lining of the nose)
Pyrexia (fever)
Chronic sinusitis (long lasting inflammation of the paranasal sinuses)
Cough
Headache (pain in head)
Abdominal distension
Abdominal pain upper
Abnormal behaviour
Acute respiratory failure

20-29:

Anxiety
Asthenia (weakness)
Biliary dyskinesia (motility disorder that affects the gallbladder and sphincter of oddi)
Cholecystitis chronic (long lasting infection of gallbladder)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Drug screen positive
End stage aids
Haemoglobin decreased
Hepatic cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue)
Hepatic lesion

30-39:

Acidosis (build-up of carbon dioxide in the blood)
Candiduria (candida in urine)
Hydronephrosis (water inside the kidney)
Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)
Nephrolithiasis (calculi in the kidneys)
Oedema peripheral (superficial swelling)
Renal failure (kidney dysfunction)
Respiratory failure (inadequate gas exchange by the respiratory system)
Staphylococcus test positive

40-49:

Pruritus (severe itching of the skin)
Stiff person syndrome
Urethral pain
Vaginal burning sensation
Vaginitis (inflammation of the vagina)
Cerebellar ataxia (loss of coordination)
Cerebellar atrophy (degeneration of the section of the brain responsible for balance, voluntary muscle movements)
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Dysarthria (speech disorder)
Fall

50-59:

Constipation
Folliculitis (infection of hair root)
Headache (pain in head)
Urticaria (rash of round, red welts on the skin that itch intensely)
Vision blurred
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Femur fracture
Fibromyalgia (a long-term condition which causes pain all over the body)
Fracture displacement
Pain in extremity

60+:

Nephrolithiasis (calculi in the kidneys)
Nausea (feeling of having an urge to vomit)
Lipids increased (excess lipid in body)
Neuropathy peripheral (surface nerve damage)
Polymyositis (inflammatory muscle disease that causes weakness of the skeletal muscles)
Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))
Urinary tract infection
Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Chronic kidney disease

What are the existing conditions these people have? *

Cystic Fibrosis (disease of the secretary glands): 12 people, 15.19%
Pain: 12 people, 15.19%
Hypersensitivity: 12 people, 15.19%
Stress And Anxiety: 7 people, 8.86%
Nausea (feeling of having an urge to vomit): 7 people, 8.86%
High Blood Pressure: 7 people, 8.86%
Urinary Tract Infection: 5 people, 6.33%
Depression: 5 people, 6.33%
Headache (pain in head): 5 people, 6.33%
High Blood Cholesterol: 5 people, 6.33%

* Approximation only. Some reports may have incomplete information.

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