Perjeta and Senna drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Perjeta (pertuzumab) and Senna (senna). Common drug interactions include white blood cell count decreased among females and abdominal pain among males.

The phase IV clinical study analyzes what interactions people have when they take Perjeta and Senna. It is created by eHealthMe based on reports of 46 people who take the same drugs from the FDA, and is updated regularly.

What is Perjeta?

Perjeta has active ingredients of pertuzumab. eHealthMe is studying from 13,388 Perjeta users. Check the latest studies of Perjeta.

What is Senna?

Senna has active ingredients of senna. It is often used in constipation. eHealthMe is studying from 37,302 Senna users. Check the latest studies of Senna.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

46 people who take Perjeta and Senna together, and have interactions are studied.

What are the common drug interactions of Perjeta and Senna, by gender? *:

female:

White blood cell count decreased
Cardiac failure
Cardiomyopathy (weakening of the heart muscle)
Death
Infusion related reaction
Sepsis (a severe blood infection that can lead to organ failure and death)
Diarrhoea
Nausea (feeling of having an urge to vomit)
Headache (pain in head)
Neuropathy peripheral (surface nerve damage)

male:

Abdominal pain
Anaemia (lack of blood)
Oral pain
Oropharyngeal pain
Skin mass
Tumour marker increased
Weight decreased
Wound
Back pain
Chest pain

What are the common drug interactions of Perjeta and Senna, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Abdominal pain
Anaemia (lack of blood)
Back pain
Chest pain
Decreased appetite
Dyspnoea (difficult or laboured respiration)
Excessive granulation tissue (excessive collagen-rich tissue which forms at the site of an injury)
Fatigue (feeling of tiredness)
Infectious pleural effusion (infectious fluid in the lung)
Oesophagitis (inflammation of oesophagus)

40-49:

Diarrhoea
Disease progression
Vomiting

50-59:

Infusion related reaction
Sepsis (a severe blood infection that can lead to organ failure and death)
Nausea (feeling of having an urge to vomit)
Diarrhoea
Headache (pain in head)
Neuropathy peripheral (surface nerve damage)
Muscle twitching
Lacrimation increased
Fatigue (feeling of tiredness)
Abdominal pain

60+:

Headache (pain in head)
Alopecia (absence of hair from areas of the body)
Leukocytosis (increased white blood cells)
Musculoskeletal chest pain (pain in chest muscle or nerve or bones)
Pleuritic pain
Vertigo
Visual impairment
Blood pressure decreased
Blood pressure increased
Discomfort

What are the existing conditions these people have? *

Breast Cancer: 35 people, 76.09%
Diarrhea: 29 people, 63.04%
Breast Cancer Metastatic: 28 people, 60.87%
Muscle Spasms (muscle contraction): 25 people, 54.35%
Cough: 23 people, 50.00%
Headache (pain in head): 23 people, 50.00%
Muscle Twitching: 22 people, 47.83%
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 22 people, 47.83%
Heart Palpitations (feelings or sensations that your heart is pounding or racing): 22 people, 47.83%
Urinary Tract Infection: 22 people, 47.83%

* Approximation only. Some reports may have incomplete information.

Do you take Perjeta and Senna?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously