Pexeva and Paxil drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Pexeva (paroxetine mesylate) and Paxil (paroxetine hydrochloride). Common drug interactions include sleep disorder among females and drug ineffective among males.

The phase IV clinical study analyzes what interactions people have when they take Pexeva and Paxil. It is created by eHealthMe based on reports of 13 people who take the same drugs from the FDA, and is updated regularly.

What is Pexeva?

Pexeva has active ingredients of paroxetine mesylate. It is often used in depression. eHealthMe is studying from 302 Pexeva users. Check the latest studies of Pexeva.

What is Paxil?

Paxil has active ingredients of paroxetine hydrochloride. It is often used in depression. eHealthMe is studying from 92,546 Paxil users. Check the latest studies of Paxil.



On Jul, 17, 2026

13 people who take Pexeva and Paxil together, and have interactions are studied.

Pexeva and Paxil drug interactions.

What are the common drug interactions of Pexeva and Paxil, by gender? *:

female:

  1. Sleep disorder
  2. Surgery
  3. Therapeutic response unexpected
  4. Type 1 diabetes mellitus
  5. Type 2 diabetes mellitus
  6. Hypotension (abnormally low blood pressure)
  7. Anaemia (lack of blood)
  8. Leukopenia (less number of white blood cells in blood)
  9. Weight increased
  10. Abdominal pain

male:

  1. Drug ineffective
  2. Abdominal discomfort
  3. Neck pain
  4. Nervousness
  5. Pain in extremity
  6. Reading disorder (problem in areas of the brain that help interpret language)
  7. Burning sensation
  8. Diarrhoea
  9. Pancreatitis (inflammation of pancreas)
  10. Suicide attempt

What are the common drug interactions of Pexeva and Paxil, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

  1. Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
  2. Electrocardiogram qt prolonged
  3. Gestational diabetes (diabetes in pregnancy)
  4. Joint sprain (an injury to joint surrounding flexible fibres)
  5. Surgery
  6. Type 1 diabetes mellitus
  7. Type 2 diabetes mellitus

40-49:

  1. Abdominal discomfort
  2. Aphasia (damage to the parts of the brain that control language)
  3. Disturbance in attention
  4. Drug hypersensitivity
  5. Drug ineffective
  6. Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
  7. Headache (pain in head)
  8. Influenza like illness
  9. Memory impairment
  10. Nausea (feeling of having an urge to vomit)

50-59:

  1. Biliary tract disorder
  2. Bipolar i disorder (mood disorder that is characterized by at least one manic or mixed episode)
  3. Cellulitis (infection under the skin)
  4. Contusion (a type of hematoma of tissue in which capillaries)
  5. Cystitis (inflammation of the wall of the bladder)
  6. Death
  7. Dehydration (dryness resulting from the removal of water)
  8. Dermatitis allergic (inflammation of the skin due allergic reaction)
  9. Diaphragmatic disorder
  10. Duodenal ulcer

60+:

  1. Disease recurrence
  2. Drug ineffective
  3. Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance)

What are the existing conditions these people have? *

  1. Stress And Anxiety: 6 people, 46.15%
  2. Bipolar Disorder (mood disorder): 3 people, 23.08%
  3. Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 1 person, 7.69%
  4. Panic Disorder: 1 person, 7.69%
  5. Insomnia (sleeplessness): 1 person, 7.69%
  6. High Blood Cholesterol: 1 person, 7.69%
  7. Breast Cancer: 1 person, 7.69%
  8. Blood Potassium Decreased: 1 person, 7.69%
  9. Bipolar Ii Disorder (characterized by at least one episode of hypomania and at least one episode of major depression): 1 person, 7.69%
  10. Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Pexeva and Paxil:

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Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Pexeva:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Paxil:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Pexeva and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Paxil and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on paroxetine mesylate and paroxetine hydrochloride (the active ingredients of Pexeva and Paxil, respectively), and Pexeva and Paxil (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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