Pexeva and Profen drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Pexeva (paroxetine mesylate) and Profen (ibuprofen). Common drug interactions include diarrhoea among females.

The phase IV clinical study analyzes what interactions people have when they take Pexeva and Profen. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Pexeva?

Pexeva has active ingredients of paroxetine mesylate. It is often used in depression. eHealthMe is studying from 302 Pexeva users. Check the latest studies of Pexeva.

What is Profen?

Profen has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 245,311 Profen users. Check the latest studies of Profen.

On Aug, 04, 2026

11 people who take Pexeva and Profen together, and have interactions are studied.

What are the common drug interactions of Pexeva and Profen, by gender? *:

female:

Diarrhoea
Nausea (feeling of having an urge to vomit)
Drug administration error
Headache (pain in head)
Hyperhidrosis (abnormally increased sweating)
Insomnia (sleeplessness)
Limb injury
Malaise (a feeling of general discomfort or uneasiness)
Alopecia (absence of hair from areas of the body)
Hair colour changes

male:

n/a

What are the common drug interactions of Pexeva and Profen, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Compartment syndrome (painful condition that occurs when pressure within the muscles builds to dangerous levels)
Contusion (a type of hematoma of tissue in which capillaries)
Dizziness
Drug administration error
Headache (pain in head)
Hyperhidrosis (abnormally increased sweating)
Insomnia (sleeplessness)
Limb injury
Malaise (a feeling of general discomfort or uneasiness)
Nausea (feeling of having an urge to vomit)

20-29:

n/a

30-39:

Chest pain
Dyspnoea (difficult or laboured respiration)
Fluid retention (an abnormal accumulation of fluid in the blood)
Weight increased

40-49:

Abortion spontaneous (naturally occurring miscarriage)

50-59:

Diarrhoea
Pancreatitis (inflammation of pancreas)
Hepatosplenomegaly (enlargement of both the liver and the spleen)
Pleural effusion (water on the lungs)
Polymyalgia rheumatica (pain in many muscles)
Abdominal distension
Nausea (feeling of having an urge to vomit)
Vomiting
Alopecia (absence of hair from areas of the body)
Hair colour changes

60+:

n/a

What are the existing conditions these people have? *

Muscle Spasms (muscle contraction): 2 people, 18.18%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 18.18%
Migraine (headache): 2 people, 18.18%
Obsessive-Compulsive Disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;): 1 person, 9.09%
Breast Cancer Stage Ii: 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

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