Phenytoin sodium and Metronidazole drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Phenytoin sodium (phenytoin sodium) and Metronidazole (metronidazole). Common drug interactions include memory impairment among females and drug ineffective among males.

The phase IV clinical study analyzes what interactions people have when they take Phenytoin sodium and Metronidazole. It is created by eHealthMe based on reports of 61 people who take the same drugs from the FDA, and is updated regularly.

What is Phenytoin sodium?

Phenytoin sodium has active ingredients of phenytoin sodium. It is often used in epilepsy. eHealthMe is studying from 6,886 Phenytoin sodium users. Check the latest studies of Phenytoin sodium.

What is Metronidazole?

Metronidazole has active ingredients of metronidazole. It is often used in vaginitis bacterial. eHealthMe is studying from 59,578 Metronidazole users. Check the latest studies of Metronidazole.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

61 people who take Phenytoin sodium and Metronidazole together, and have interactions are studied.

Phenytoin sodium and Metronidazole drug interactions.

What are the common drug interactions of Phenytoin Sodium and Metronidazole, by gender? *:

female:

Memory impairment
Migraine (headache)
Mouth ulceration (mouth ulcers)
Myoclonus (a brief, involuntary twitching of a muscle or a group of muscles)
Open fracture
Oral surgery
Pain
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Pathological fracture (broken bone caused by disease)
Postoperative wound infection

male:

Drug ineffective
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Bone marrow failure
Nausea (feeling of having an urge to vomit)
Sepsis (a severe blood infection that can lead to organ failure and death)
Abdominal tenderness
Antidiuretic hormone abnormality
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Bile duct obstruction (blockage in the tubes that carry bile from the liver to the gallbladder)
Blood sodium decreased

What are the common drug interactions of Phenytoin Sodium and Metronidazole, by age (0-1 to 60+)? *:

0-1:

Drug ineffective
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Haematotoxicity (toxins that destroy red blood cells)
Alanine aminotransferase increased
Fungal infection
Lung infection
Sepsis (a severe blood infection that can lead to organ failure and death)

2-9:

Drug ineffective
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Haematotoxicity (toxins that destroy red blood cells)
Bacterial infection
Lung infection
Alanine aminotransferase increased
Sepsis (a severe blood infection that can lead to organ failure and death)

10-19:

Drug ineffective
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Haematotoxicity (toxins that destroy red blood cells)
Bacterial infection
International normalised ratio increased
Kidney transplant rejection
Lung infection

20-29:

Chills (felling of cold)
Drug ineffective
Dyspnoea (difficult or laboured respiration)
Emotional distress
Haematocrit increased
Haemoglobin increased
Hypoxic-ischaemic encephalopathy (a condition that occurs when the entire brain is deprived of an adequate oxygen supply, but the deprivation isn't total)
Lymphocyte count decreased
Malaise (a feeling of general discomfort or uneasiness)
Mean cell haemoglobin decreased (less than normal haemoglobin per red blood cell in a sample of blood)

30-39:

Arrhythmia (irregular heartbeat)
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Cerebral ischaemia (insufficient blood flow to the brain to meet metabolic demand)
Electrolyte imbalance
Loss of consciousness
Torsade de pointes (a abnormal heart rate with abnormal beating pattern)
Drug ineffective
Haemodynamic instability (disturbances in the blood movement in our body)
Hepatic function abnormal
Myoclonus (a brief, involuntary twitching of a muscle or a group of muscles)

40-49:

Alanine aminotransferase increased
Aspartate aminotransferase increased
Blood alkaline phosphatase increased
Purple glove syndrome (skin disease in which the extremities become swollen, discoloured and painful)
Cardiogenic shock (inadequate circulation of blood)
Connective tissue disorder (any disease that has the connective tissues of the body)
Crepitations (noises are produced by the rubbing of parts one against the other)
Cyanosis (lack of oxygen in body leads to blue appearance of skin ,mucous membrane nails)
Depressed level of consciousness
Dyspnoea (difficult or laboured respiration)

50-59:

Myelodysplastic syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Chronic kidney disease
Febrile neutropenia (fever with reduced white blood cells)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Impaired gastric emptying
Productive cough
Pyrexia (fever)
Renal failure (kidney dysfunction)
Anaphylactic reaction (serious allergic reaction)

60+:

Fall
Abdominal tenderness
Infection
Nystagmus (a condition of involuntary eye movement)
Pneumonia
Somnolence (a state of near-sleep, a strong desire for sleep)
Tremor (trembling or shaking movements in one or more parts of your body)
Atypical femur fracture
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Comminuted fracture (bone has broken into several pieces)

What are the existing conditions these people have? *

Bone Marrow Conditioning Regimen: 10 people, 16.39%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 9 people, 14.75%
Pain: 6 people, 9.84%
Insomnia (sleeplessness): 6 people, 9.84%
High Blood Pressure: 6 people, 9.84%
Stress And Anxiety: 5 people, 8.20%
Status Epilepticus (a life-threatening condition in which the brain is in a state of persistent seizure): 5 people, 8.20%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 5 people, 8.20%
Nausea (feeling of having an urge to vomit): 5 people, 8.20%
Depression: 5 people, 8.20%

* Approximation only. Some reports may have incomplete information.

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