Samsca and Blopress drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Samsca (tolvaptan) and Blopress (candesartan cilexetil). Common drug interactions include hypernatraemia among females and alanine aminotransferase increased among males.

The phase IV clinical study analyzes what interactions people have when they take Samsca and Blopress. It is created by eHealthMe based on reports of 66 people who take the same drugs from the FDA, and is updated regularly.

What is Samsca?

Samsca has active ingredients of tolvaptan. eHealthMe is studying from 8,139 Samsca users. Check the latest studies of Samsca.

What is Blopress?

Blopress has active ingredients of candesartan cilexetil. It is often used in high blood pressure. eHealthMe is studying from 7,479 Blopress users. Check the latest studies of Blopress.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

66 people who take Samsca and Blopress together, and have interactions are studied.

What are the common drug interactions of Samsca and Blopress, by gender? *:

female:

Hypernatraemia (an abnormally high plasma concentration of sodium ions)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Arthralgia (joint pain)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Dyspnoea (difficult or laboured respiration)
Emotional distress
Fear
General physical health deterioration (weak health status)
Injury

male:

Alanine aminotransferase increased
Aspartate aminotransferase increased
Folliculitis (infection of hair root)
Gastric polyps (abnormal growth of stomach tissue projecting from a mucous membrane)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Haemophilic arthropathy (permanent joint disease)
Hepatitis c
Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)
Hypertriglyceridaemia (excess of triglycerides in the blood)
Oesophageal candidiasis (fungal infection of oesophagus)

What are the common drug interactions of Samsca and Blopress, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Abdominal pain
Altered state of consciousness (altered state of mind)
Cholangitis acute (rapid infection of bile duct)
Enterocolitis (inflammation of the digestive tract, involving enteritis of the small intestine and colitis of the colon)
Haematuria (presence of blood in urine)
Pyrexia (fever)
Renal impairment (severely reduced kidney function)

40-49:

Cerebral infarction (less blood supply to brain resulting tissue damage)
Duodenal ulcer haemorrhage (bleeding duodenal ulcer)
Fluid retention (an abnormal accumulation of fluid in the blood)
Haemoglobin decreased
Shock haemorrhagic (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin due to excess bleeding)
Abscess limb (limb infection)
Anaemia (lack of blood)
Arthritis bacterial (form of joint disorder that involves inflammation of one or more joints due to bacterial infection)
C-reactive protein increased
Cellulitis (infection under the skin)

50-59:

Right ventricular failure (right half of the heart fails to work)
Thirst
Thrombocytopenia (decrease of platelets in blood)
Uterine cancer
Uterine haemorrhage (uterine bleeding)
White blood cell count increased
Hypocalcaemia (levels of calcium in blood serum are abnormally low)
Hypokalaemia (low potassium)
Nephrogenic anaemia (anaemia due to kidney disease)
Oedema due to renal disease (fluid collection in tissue due to kidney disease)

60+:

Alanine aminotransferase increased
Aspartate aminotransferase increased
Renal impairment (severely reduced kidney function)
Ascites (accumulation of fluid in the abdominal cavity)
Diarrhoea
Disseminated intravascular coagulation (systemic activation of blood coagulation)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Infusion site erythema (reddening of the skin at infusion site)
Infusion site induration
Infusion site pain

What are the existing conditions these people have? *

Cardiac Failure: 22 people, 33.33%
Fluid Retention (an abnormal accumulation of fluid in the blood): 12 people, 18.18%
Mycobacterium Avium Complex Infection: 7 people, 10.61%
Hiv Infection: 7 people, 10.61%
Hyperuricaemia (level of uric acid in the blood that is abnormally high): 6 people, 9.09%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 5 people, 7.58%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 4 people, 6.06%
Haemophilic Arthropathy (permanent joint disease): 4 people, 6.06%
Enlarged Prostate: 4 people, 6.06%
Cardiac Failure Congestive: 4 people, 6.06%

* Approximation only. Some reports may have incomplete information.

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