Phenytoin and Nicotine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Phenytoin (phenytoin) and Nicotine (nicotine). Common drug interactions include dyspnoea among females and ataxia among males.

The phase IV clinical study analyzes what interactions people have when they take Phenytoin and Nicotine. It is created by eHealthMe based on reports of 26 people who take the same drugs from the FDA, and is updated regularly.

What is Phenytoin?

Phenytoin has active ingredients of phenytoin. It is often used in epilepsy. eHealthMe is studying from 15,753 Phenytoin users. Check the latest studies of Phenytoin.

What is Nicotine?

Nicotine has active ingredients of nicotine. It is often used in quit smoking. eHealthMe is studying from 20,443 Nicotine users. Check the latest studies of Nicotine.

On Jul, 10, 2026

26 people who take Phenytoin and Nicotine together, and have interactions are studied.

Phenytoin and Nicotine drug interactions.

What are the common drug interactions of Phenytoin and Nicotine, by gender? *:

female:

Dyspnoea (difficult or laboured respiration)
Non-small cell lung cancer (type of epithelial lung cancer)
Pneumonia
Respiratory failure (inadequate gas exchange by the respiratory system)
Abdominal pain
Asthma
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Choking sensation (feeling of obstruction in respiratory system)
Confusional state
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)

male:

Ataxia (loss of full control of bodily movements)
Blood cholesterol increased
Alcohol detoxification
Alcohol use
Anticonvulsant drug level decreased
Anticonvulsant drug level increased
Antidepressant drug level increased
Bronchopneumonia (inflammation of the lungs, arising in the bronchi or bronchioles)
Cardiac arrest
Cardiac disorder

What are the common drug interactions of Phenytoin and Nicotine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Alcohol use
Completed suicide (act of taking one's own life)
Depression
Drug ineffective
Gun shot wound
Haemorrhage intracranial (bleeding within the skull)
Head injury
Skull fracture
Traumatic brain injury (brain injury due to trauma)
Unintended pregnancy (unwanted pregnancies as well as those that are mistimed)

30-39:

Brain oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain)
Drug toxicity
Pulmonary oedema (fluid accumulation in the lungs)
Adhesion
Anticonvulsant drug level decreased
Antidepressant drug level increased
Bronchopneumonia (inflammation of the lungs, arising in the bronchi or bronchioles)
Cardiac arrest
Cardiac disorder
Cell death

40-49:

Dyspnoea (difficult or laboured respiration)
Alcohol detoxification
Asthma
Choking sensation (feeling of obstruction in respiratory system)
Confusional state
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Drug toxicity
Erythema (redness of the skin)
Hallucination (an experience involving the perception of something not present)
Ill-defined disorder

50-59:

Death
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Non-small cell lung cancer (type of epithelial lung cancer)
Pneumonia
Respiratory failure (inadequate gas exchange by the respiratory system)
Vision blurred
Weight decreased
Abdominal pain
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)

60+:

Ataxia (loss of full control of bodily movements)
Anticonvulsant drug level increased
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Drug ineffective
Headache (pain in head)
Hemiparesis (weakness on one side of the body)
Muscular weakness (muscle weakness)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Tremor (trembling or shaking movements in one or more parts of your body)

What are the existing conditions these people have? *

Stress And Anxiety: 2 people, 7.69%
Pulmonary Embolism (blockage of the main artery of the lung): 2 people, 7.69%
Pain: 2 people, 7.69%
High Blood Pressure: 2 people, 7.69%
Foetal Exposure During Pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect): 2 people, 7.69%
Depression: 2 people, 7.69%
Cough: 2 people, 7.69%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 2 people, 7.69%

* Approximation only. Some reports may have incomplete information.

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