Phenytoin and Ultram drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Phenytoin (phenytoin) and Ultram (tramadol hydrochloride). Common drug interactions include illusion among females and asthenia among males.

The phase IV clinical study analyzes what interactions people have when they take Phenytoin and Ultram. It is created by eHealthMe based on reports of 39 people who take the same drugs from the FDA, and is updated regularly.

What is Phenytoin?

Phenytoin has active ingredients of phenytoin. It is often used in epilepsy. eHealthMe is studying from 15,753 Phenytoin users. Check the latest studies of Phenytoin.

What is Ultram?

Ultram has active ingredients of tramadol hydrochloride. It is often used in pain. eHealthMe is studying from 28,425 Ultram users. Check the latest studies of Ultram.

On Jul, 09, 2026

39 people who take Phenytoin and Ultram together, and have interactions are studied.

What are the common drug interactions of Phenytoin and Ultram, by gender? *:

female:

Illusion
Insomnia (sleeplessness)
Loss of consciousness
Lymphoma (cancer that begins in immune system cells)
Muscle twitching
Prothrombin level decreased
Recurrent cancer (repeated cancer)
Renal failure (kidney dysfunction)
Suicidal ideation
Tachycardia (a heart rate that exceeds the range of 100 beats/min)

male:

Asthenia (weakness)
Candidiasis (candidiasis or thrush is a fungal infection)
Hypophagia (reduced food intake)
Lung infiltration (a substance that normally includes fluid, inflammatory exudates or cells that fill a region of lung)
Nausea (feeling of having an urge to vomit)
Pneumonia
Productive cough
Pyrexia (fever)
Rhonchi (abnormal breath sounds)
Sputum discoloured

What are the common drug interactions of Phenytoin and Ultram, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Back injury
Blood cholesterol increased
Cyst (a closed sac)
Fall
Joint injury
Neck injury
Pulmonary embolism (blockage of the main artery of the lung)
Thyroid neoplasm (tumour of thyroid)
Convulsions (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled of muscles contract and relax rapidly and repeatedly)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)

40-49:

Chronic kidney disease
Death
Suicide attempt
Alcoholism (problems with alcohol)
Bipolar disorder (mood disorder)
Contusion (a type of hematoma of tissue in which capillaries)
Gynaecomastia (enlargement of the gland tissue of the male breast)
Herpes zoster
Hyperglycaemia (high blood sugar)
Hypotension (abnormally low blood pressure)

50-59:

Anger
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Personality change
Abnormal behaviour
Completed suicide (act of taking one's own life)
Dyspnoea (difficult or laboured respiration)
Gun shot wound
Hypersensitivity
Hypotension (abnormally low blood pressure)
Pulmonary embolism (blockage of the main artery of the lung)

60+:

Asthenia (weakness)
Candidiasis (candidiasis or thrush is a fungal infection)
Nausea (feeling of having an urge to vomit)
Pneumonia
Productive cough
Pyrexia (fever)
Rhonchi (abnormal breath sounds)
Sputum discoloured
Upper respiratory tract infection
Wheezing (a high-pitched whistling sound made while you breath)

What are the existing conditions these people have? *

Infection: 10 people, 25.64%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 10 people, 25.64%
High Blood Cholesterol: 5 people, 12.82%
Blood Pressure Abnormal: 5 people, 12.82%
Cardiac Disorder: 5 people, 12.82%
High Blood Pressure: 5 people, 12.82%
Depression: 4 people, 10.26%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 4 people, 10.26%
Asthma: 4 people, 10.26%
Renal Injury (kidney injury): 4 people, 10.26%

* Approximation only. Some reports may have incomplete information.

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