Pimozide and Aripiprazole drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Pimozide (pimozide) and Aripiprazole (aripiprazole). Common drug interactions include hypersexuality among females and weight increased among males.

The phase IV clinical study analyzes what interactions people have when they take Pimozide and Aripiprazole. It is created by eHealthMe based on reports of 93 people who take the same drugs from the FDA, and is updated regularly.

What is Pimozide?

Pimozide has active ingredients of pimozide. eHealthMe is studying from 507 Pimozide users. Check the latest studies of Pimozide.

What is Aripiprazole?

Aripiprazole has active ingredients of aripiprazole. It is often used in depression. eHealthMe is studying from 39,143 Aripiprazole users. Check the latest studies of Aripiprazole.

On Jul, 27, 2026

93 people who take Pimozide and Aripiprazole together, and have interactions are studied.

Pimozide and Aripiprazole drug interactions.

What are the common drug interactions of Pimozide and Aripiprazole, by gender? *:

female:

Hypersexuality
Abdominal distension
Abdominal pain
Abnormal faeces (abnormal stool)
Abortion (termination of pregnancy)
Akathisia (a movement disorder characterized by a feeling of inner restlessness)
Angioedema (rapid swelling of the dermis)
Apathy
Asthma
Blood glucose increased

male:

Weight increased
Lethargy (tiredness)
Dystonia (abnormal muscle tone)
Anxiety
Neuroleptic malignant syndrome (a life-threatening neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic agents)
Drug intolerance (drug sensitivity)
Extrapyramidal disorder (involuntary muscle spasms in the face and neck)
Catatonia (unresponsive to external stimuli)
Vomiting
Loss of consciousness

What are the common drug interactions of Pimozide and Aripiprazole, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Weight increased
Electrocardiogram qt prolonged
Galactorrhoea (secretion of breast milk in men)
Blood prolactin increased
Suicidal ideation
Drug ineffective
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Tic (a sudden, repetitive, nonrhythmic motor movement or vocalization involving discrete muscle groups)
Lethargy (tiredness)
Catatonia (unresponsive to external stimuli)

20-29:

Affective disorder (mental disorder)
Blood prolactin increased
Decreased appetite
Electrocardiogram qt prolonged
Galactorrhoea (secretion of breast milk in men)
Lethargy (tiredness)
Loss of consciousness
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Suicidal ideation
Tic (a sudden, repetitive, nonrhythmic motor movement or vocalization involving discrete muscle groups)

30-39:

Dystonia (abnormal muscle tone)
Vomiting
Weight increased
Drug ineffective
Parkinsonism (degenerative disorder of the central nervous system characterized by tremor and impaired muscular coordination)
Somnolence (a state of near-sleep, a strong desire for sleep)
Anxiety
Blood sodium decreased
Drug intolerance (drug sensitivity)
Dry skin

40-49:

Swollen tongue (swelling of tongue)
Tendon pain
Tongue discolouration (colour change of tongue)
Tongue ulceration (ulcers on tongue)
Trimethylaminuria (trimethylamine builds up in the body of patients with trimethylaminuria. the trimethylamine gets released in the person's sweat, urine, reproductive fluids, and breath, giving off a strong fishy or body odour)
Uterine spasm
Very low density lipoprotein increased
Agitation (state of anxiety or nervous excitement)
Drug ineffective
Hyperhidrosis (abnormally increased sweating)

50-59:

Drug ineffective
Parkinsonism (degenerative disorder of the central nervous system characterized by tremor and impaired muscular coordination)
Neutropenia (an abnormally low number of neutrophils)
Tic (a sudden, repetitive, nonrhythmic motor movement or vocalization involving discrete muscle groups)
Angioedema (rapid swelling of the dermis)
Apathy
Depressed mood
Dystonia (abnormal muscle tone)
Face oedema (swelling of face)
Hypersensitivity

60+:

Extrapyramidal disorder (involuntary muscle spasms in the face and neck)
Drug intolerance (drug sensitivity)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Suicidal ideation
Tic (a sudden, repetitive, nonrhythmic motor movement or vocalization involving discrete muscle groups)
Increased appetite
Metabolic syndrome (a combination of the medical disorders that, when occurring together, increase the risk of developing cardiovascular disease)
Weight increased
Anxiety
Blood prolactin increased

What are the existing conditions these people have? *

Gilles De La Tourette Syndrome (a condition that causes people to make repeated, quick movements or sounds that they cannot control): 35 people, 37.63%
Stress And Anxiety: 16 people, 17.20%
Psychotic Disorder: 14 people, 15.05%
Tic (a sudden, repetitive, nonrhythmic motor movement or vocalization involving discrete muscle groups): 10 people, 10.75%
Autism Spectrum Disorder (developmental disabilities that can cause significant social, communication and behavioural challenges): 9 people, 9.68%
Sleep Disorder: 6 people, 6.45%
Parkinson's Disease: 6 people, 6.45%
Obsessive-Compulsive Disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;): 6 people, 6.45%
Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 6 people, 6.45%
Suicide Attempt: 5 people, 5.38%

* Approximation only. Some reports may have incomplete information.

Do you take Pimozide and Aripiprazole?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously