Piperacillin and Ambien drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Piperacillin (piperacillin sodium) and Ambien (zolpidem tartrate). Common drug interactions include neurotoxicity among females and pyrexia among males.

The phase IV clinical study analyzes what interactions people have when they take Piperacillin and Ambien. It is created by eHealthMe based on reports of 21 people who take the same drugs from the FDA, and is updated regularly.

What is Piperacillin?

Piperacillin has active ingredients of piperacillin sodium. eHealthMe is studying from 5,597 Piperacillin users. Check the latest studies of Piperacillin.

What is Ambien?

Ambien has active ingredients of zolpidem tartrate. It is often used in insomnia. eHealthMe is studying from 93,519 Ambien users. Check the latest studies of Ambien.

On Jul, 12, 2026

21 people who take Piperacillin and Ambien together, and have interactions are studied.

Piperacillin and Ambien drug interactions.

What are the common drug interactions of Piperacillin and Ambien, by gender? *:

female:

Neurotoxicity (when the exposure to natural or artificial toxic substances, which are called neurotoxins, alters the normal activity of the nervous system)
Vith nerve paralysis
Dysarthria (speech disorder)
Pyrexia (fever)
Headache (pain in head)
Cardiac failure congestive
Dehydration (dryness resulting from the removal of water)
Dyspnoea (difficult or laboured respiration)
Nausea (feeling of having an urge to vomit)
Pain

male:

Pyrexia (fever)
Anaemia (lack of blood)
Cardiorenal syndrome (kidney failure and heart failure)
Hypotension (abnormally low blood pressure)
Peripheral vascular disorder
Pulmonary oedema (fluid accumulation in the lungs)
Confusional state
Decubitus ulcer (a chronic ulcer of the skin caused by prolonged pressure on it)
Diarrhoea
Dyspnoea (difficult or laboured respiration)

What are the common drug interactions of Piperacillin and Ambien, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Gastrointestinal haemorrhage (bleeding gastrointestinal tract)

40-49:

n/a

50-59:

Pain in extremity
Platelet count decreased
Pneumonia klebsiella (pneumonia caused by bacteria klebsiella)
Renal failure acute (rapid kidney dysfunction)
Sepsis (a severe blood infection that can lead to organ failure and death)
Skin ulcer
Systemic candida (whole body fungal infection)
Dysarthria (speech disorder)
Headache (pain in head)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)

60+:

Pleural effusion (water on the lungs)
Pyrexia (fever)
Abdominal discomfort
Abdominal pain
Angina pectoris (chest pain due to ischemia of the heart muscle)
Anxiety
Apnoeic attack
Atrial flutter (an abnormal heart rhythm that occurs in the atria of the heart)
Blood creatinine decreased
Bradycardia (abnormally slow heart action)

What are the existing conditions these people have? *

Nausea (feeling of having an urge to vomit): 6 people, 28.57%
Respiratory Disorder (respiratory disease): 5 people, 23.81%
Anaesthesia: 5 people, 23.81%
Pain In Extremity: 3 people, 14.29%
Fever: 3 people, 14.29%
Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 3 people, 14.29%
Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 2 people, 9.52%
Dyspnea (difficult or laboured breathing): 2 people, 9.52%
Chest Pain: 2 people, 9.52%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 2 people, 9.52%

* Approximation only. Some reports may have incomplete information.

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