Plan b and Advil drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Plan b (levonorgestrel) and Advil (ibuprofen). Common drug interactions include menstruation irregular among females.

The phase IV clinical study analyzes what interactions people have when they take Plan b and Advil. It is created by eHealthMe based on reports of 35 people who take the same drugs from the FDA, and is updated regularly.

What is Plan b?

Plan b has active ingredients of levonorgestrel. It is often used in birth control. eHealthMe is studying from 38,623 Plan b users. Check the latest studies of Plan b.

What is Advil?

Advil has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 62,533 Advil users. Check the latest studies of Advil.

On Jul, 11, 2026

35 people who take Plan b and Advil together, and have interactions are studied.

What are the common drug interactions of Plan B and Advil, by gender? *:

female:

Menstruation irregular
Vaginal haemorrhage (vaginal bleeding)
Menorrhagia (an abnormally heavy bleeding and prolonged menstrual period at regular intervals)
Abdominal distension
Abdominal pain lower
Breast tenderness
Syncope (loss of consciousness with an inability to maintain postural tone)
Dyspepsia (indigestion)
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)

male:

n/a

What are the common drug interactions of Plan B and Advil, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Vaginal haemorrhage (vaginal bleeding)
Menstruation irregular
Vaginal discharge
Nausea (feeling of having an urge to vomit)
Menorrhagia (an abnormally heavy bleeding and prolonged menstrual period at regular intervals)
Syncope (loss of consciousness with an inability to maintain postural tone)
Abdominal tenderness
Breast tenderness
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)

20-29:

Menstruation irregular
Dyspepsia (indigestion)
Gait disturbance
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hypersensitivity
Hypertension (high blood pressure)
Menstruation delayed (late menstruation cycle)
Nausea (feeling of having an urge to vomit)
Oedema peripheral (superficial swelling)
Oesophagitis (inflammation of oesophagus)

30-39:

Pain in extremity
Polymenorrhoea (menstrual disorder)
Pregnancy after post coital contraception
Haemorrhage (bleeding)
Malaise (a feeling of general discomfort or uneasiness)
Urinary tract infection
Vaginal haemorrhage (vaginal bleeding)
Vomiting
Menstruation delayed (late menstruation cycle)
Abdominal pain lower

40-49:

Abdominal pain
Breast swelling
Dysmenorrhoea (painful menstruation)
Nausea (feeling of having an urge to vomit)
Vaginal haemorrhage (vaginal bleeding)

50-59:

n/a

60+:

n/a

What are the existing conditions these people have? *

Headache (pain in head): 8 people, 22.86%
Urinary Tract Infection: 2 people, 5.71%
Oropharyngeal Pain: 2 people, 5.71%
Nerve Compression: 2 people, 5.71%

* Approximation only. Some reports may have incomplete information.

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