Plaquenil and Levofloxacin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Plaquenil (hydroxychloroquine sulfate) and Levofloxacin (levofloxacin; sodium chloride). Common drug interactions include laceration among females and lung disorder among males.

The phase IV clinical study analyzes what interactions people have when they take Plaquenil and Levofloxacin. It is created by eHealthMe based on reports of 16 people who take the same drugs from the FDA, and is updated regularly.

What is Plaquenil?

Plaquenil has active ingredients of hydroxychloroquine sulfate. It is often used in systemic lupus erythematosus. eHealthMe is studying from 91,018 Plaquenil users. Check the latest studies of Plaquenil.

What is Levofloxacin?

Levofloxacin has active ingredients of levofloxacin; sodium chloride. It is often used in sinusitis. eHealthMe is studying from 16,335 Levofloxacin users. Check the latest studies of Levofloxacin.

On Jul, 15, 2026

16 people who take Plaquenil and Levofloxacin together, and have interactions are studied.

Plaquenil and Levofloxacin drug interactions.

What are the common drug interactions of Plaquenil and Levofloxacin, by gender? *:

female:

Laceration (tearing of soft body tissue)
Lung infiltration (a substance that normally includes fluid, inflammatory exudates or cells that fill a region of lung)
Lung neoplasm malignant (cancer tumour of lung)
Mass
Metaplasia (change in the type of adult cells in a tissue to a form abnormal for that tissue)
Metastases to bone (cancer spreads to bone)
Migraine (headache)
Muscle spasms (muscle contraction)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Nephrolithiasis (calculi in the kidneys)

male:

Lung disorder (lung disease)
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)
Asthenia (weakness)
Confusional state
Cough
Decreased appetite
Diabetes mellitus inadequate control
Disease progression
Diverticulum intestinal (a pouch that is attached to the first part of the small intestine)
Drug hypersensitivity

What are the common drug interactions of Plaquenil and Levofloxacin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Acanthamoeba infection (acanthamoeba infection is a cutaneous condition)
Encephalitis (inflammation of the brain)
Erythema (redness of the skin)
Oedema (fluid collection in tissue)
Urticaria (rash of round, red welts on the skin that itch intensely)

20-29:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Arthralgia (joint pain)
Atelectasis (partial or complete collapse of the lung)
Back pain
Barrett's oesophagus (barrett's oesophagus is a disorder in which the lining of the oesophagus (the tube that carries food from the throat to the stomach) is damaged by stomach acid and changed to a lining similar to that of the stomach)
Bladder diverticulum (pouch like projection in the bladder, by birth or acquired)
Blood pressure decreased
Bone lesion (bone with abnormalities. bone lesions can result from growth formations, infections, or injuries)
Cardiomegaly (increased size of heart than normal)

30-39:

n/a

40-49:

International normalised ratio increased

50-59:

Arthralgia (joint pain)
Pyrexia (fever)
Blood potassium decreased
Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Viral infection
Adverse event
Asthenia (weakness)
Asthma
Bladder pain
Blood pressure increased

60+:

Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)
Cardiac failure
Anaemia (lack of blood)
Asthenia (weakness)
Bacterial sepsis
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cardiac failure congestive
Chills (felling of cold)
Confusional state
Cough

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 12.50%
Tracheobronchitis (an inflammation or infection, which affects the trachea and bronchi of respiratory tract): 1 person, 6.25%
Migraine (headache): 1 person, 6.25%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 1 person, 6.25%
Cytomegalovirus Infection: 1 person, 6.25%
Erection Problems: 1 person, 6.25%
Fungal Infection: 1 person, 6.25%
Hypercoagulation (increased tendency for clotting of the blood): 1 person, 6.25%
Insomnia (sleeplessness): 1 person, 6.25%
Metastatic Renal Cell Carcinoma (spreadable kidney cell tumour): 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

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