Plavix and Nyquil drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Plavix (clopidogrel bisulfate) and Nyquil (acetaminophen / dextromethorphan / doxylamine / pseudoephedrine). Common drug interactions include pneumonia among females and cerebrovascular accident among males.

The phase IV clinical study analyzes what interactions people have when they take Plavix and Nyquil. It is created by eHealthMe based on reports of 24 people who take the same drugs from the FDA, and is updated regularly.

What is Plavix?

Plavix has active ingredients of clopidogrel bisulfate. It is often used in stent. eHealthMe is studying from 151,179 Plavix users. Check the latest studies of Plavix.

What is Nyquil?

Nyquil has active ingredients of acetaminophen / dextromethorphan / doxylamine / pseudoephedrine. It is often used in cold symptoms. eHealthMe is studying from 2,240 Nyquil users. Check the latest studies of Nyquil.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

24 people who take Plavix and Nyquil together, and have interactions are studied.

What are the common drug interactions of Plavix and Nyquil, by gender? *:

female:

Pneumonia
Chest pain
Fatigue (feeling of tiredness)
Dyspnoea (difficult or laboured respiration)
Addison's disease (addison's disease, a hormonal disorder disease)
Asthma
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cardiac arrest
Cardiomegaly (increased size of heart than normal)
Cerebral disorder (brain disease)

male:

Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Abnormal behaviour
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Dysarthria (speech disorder)
Enuresis (repeated inability to control urination)
Fatigue (feeling of tiredness)
Hyperhidrosis (abnormally increased sweating)
Nasopharyngitis (inflammation of the nasopharynx)
Subdural haematoma (blood collects between the skull and the surface of the brain)
Syncope (loss of consciousness with an inability to maintain postural tone)

What are the common drug interactions of Plavix and Nyquil, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Chest pain
Fatigue (feeling of tiredness)
Hypertension (high blood pressure)
Addison's disease (addison's disease, a hormonal disorder disease)
Asthma
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cardiac arrest
Cardiomegaly (increased size of heart than normal)
Cerebral disorder (brain disease)
Chills (felling of cold)

50-59:

Pneumonia

60+:

Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Abnormal behaviour
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Dysarthria (speech disorder)
Enuresis (repeated inability to control urination)
Fatigue (feeling of tiredness)
Hyperhidrosis (abnormally increased sweating)
Nasopharyngitis (inflammation of the nasopharynx)
Subdural haematoma (blood collects between the skull and the surface of the brain)
Syncope (loss of consciousness with an inability to maintain postural tone)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 8 people, 33.33%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 8 people, 33.33%
Asthma: 4 people, 16.67%
Weight Loss: 3 people, 12.50%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 3 people, 12.50%
Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 2 people, 8.33%
Adverse Event: 2 people, 8.33%

* Approximation only. Some reports may have incomplete information.

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