Subutex and Gastrointestinal disorder - a phase IV clinical study of FDA data

Summary:

Gastrointestinal disorder is reported as a side effect among people who take Subutex (buprenorphine hydrochloride), especially for people who are male, 40-49 old, have been taking the drug for < 1 month also take Suboxone, and have Drug dependence.

The phase IV clinical study analyzes which people have Gastrointestinal disorder when taking Subutex. It is created by eHealthMe based on reports of 8,309 people who have side effects when taking Subutex from the FDA, and is updated regularly.

What is Subutex?

Subutex has active ingredients of buprenorphine hydrochloride. It is often used in opiate withdrawal. eHealthMe is studying from 8,763 Subutex users. Check the latest studies of Subutex.

What is Gastrointestinal disorder?

Gastrointestinal disorder (functional problems of gastrointestinal tract) is found to be associated with 2,093 drugs and 1,909 conditions by eHealthMe. Check the latest studies of Gastrointestinal disorder.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

8,309 people reported to have side effects when taking Subutex.
Among them, 20 people (0.24%) have Gastrointestinal disorder.

Could Subutex cause Gastrointestinal disorder?

Among these 20 people:

How long have people been on Subutex when they have Gastrointestinal disorder? *

What is the gender of people who have Gastrointestinal disorder when taking Subutex? *

female: 47.37 %
male: 52.63 %

What is the age of people who have Gastrointestinal disorder when taking Subutex? *

What are other drugs people take besides Subutex? *

Suboxone: 4 people, 20.00%
Valium: 3 people, 15.00%
Revia: 2 people, 10.00%
Ziagen: 1 person, 5.00%
Nicotine: 1 person, 5.00%
Cymbalta: 1 person, 5.00%
Dilaudid: 1 person, 5.00%
Epivir: 1 person, 5.00%
Hydrocodone Bitartrate And Acetaminophen: 1 person, 5.00%
Kaletra: 1 person, 5.00%

What are other side effects people have besides Gastrointestinal disorder? *

Drug Dependence: 4 people, 20.00%
Depression: 4 people, 20.00%
Headache (pain in head): 4 people, 20.00%
Hallucinations (sensations that appear real but are created by your mind): 3 people, 15.00%
Drug Abuse: 3 people, 15.00%
Agitation (state of anxiety or nervous excitement): 3 people, 15.00%
Joint Pain: 3 people, 15.00%
Dermatitis Allergic (inflammation of the skin due allergic reaction): 2 people, 10.00%
Muscle Aches (muscle pain): 2 people, 10.00%
Miosis (constriction of the pupil of the eye, resulting from a normal response to an increase in light): 2 people, 10.00%

What are the existing conditions these people have? *

Drug Dependence: 6 people, 30.00%
Depression: 2 people, 10.00%
Alcoholism (problems with alcohol): 2 people, 10.00%
Neuropathy Peripheral (surface nerve damage): 1 person, 5.00%
Insomnia (sleeplessness): 1 person, 5.00%
Hiv Infection: 1 person, 5.00%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 1 person, 5.00%

* Approximation only. Some reports may have incomplete information.

Do you take Subutex and have Gastrointestinal disorder?

- Check whether Gastrointestinal disorder is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Subutex:

Subutex (8,763 reports)

Browse all side effects of Subutex:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Gastrointestinal disorder:

Gastrointestinal disorder (2,093 drugs)

Browse all the conditions that are associated with Gastrointestinal disorder:

Gastrointestinal disorder (1,909 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on buprenorphine hydrochloride (the active ingredients of Subutex) and Subutex (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.