Plendil and Clonazepam drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Plendil (felodipine) and Clonazepam (clonazepam). Common drug interactions include left ventricular failure among females and dyspnoea among males.
The phase IV clinical study analyzes what interactions people have when they take Plendil and Clonazepam. It is created by eHealthMe based on reports of 28 people who take the same drugs from the FDA, and is updated regularly.
What is Plendil?
Plendil has active ingredients of felodipine. It is often used in high blood pressure. eHealthMe is studying from 4,990 Plendil users. Check the latest studies of Plendil.
What is Clonazepam?
Clonazepam has active ingredients of clonazepam. It is often used in stress and anxiety. eHealthMe is studying from 146,272 Clonazepam users. Check the latest studies of Clonazepam.
eHealthMe: drug outcomes in the real world
eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.
28 people who take Plendil and Clonazepam together, and have interactions are studied.

What are the common drug interactions of Plendil and Clonazepam, by gender? *:
female:
- Left ventricular failure (left ventricle fails to contract forcefully)
- Ligament injury
- Ligament rupture (tear in ligament)
- Limb injury
- Medical device pain (pain due to medical device)
- Multiple drug overdose
- Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
- Oedema peripheral (superficial swelling)
- Pain in limb
- Panic reaction
male:
- Dyspnoea (difficult or laboured respiration)
- Bradycardia (abnormally slow heart action)
- Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
- Decreased appetite
- Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
- Diabetes mellitus non insulin-dependent
- Early satiety (feeling full before completing a normal sized meal)
- Extravasation blood (leakage of blood from a vessel into tissues)
- Hypoxia (low oxygen in tissues)
- Influenza
What are the common drug interactions of Plendil and Clonazepam, by age (0-1 to 60+)? *:
0-1:
n/a
2-9:
n/a
10-19:
n/a
20-29:
n/a
30-39:
n/a
40-49:
n/a
50-59:
- Procedural pain
- Pulmonary embolism (blockage of the main artery of the lung)
- Rash
- Rotator cuff syndrome (a spectrum of conditions affecting the rotator cuff tendons of the shoulder)
- Shoulder pain
- Social problem
- Somnolence (a state of near-sleep, a strong desire for sleep)
- Spinal column stenosis (narrowing of spinal column)
- Spinal decompression (relief of pressure on one or many pinched nerves (neural impingement) of the spinal column)
- Spinal fusion surgery
60+:
- Acute respiratory distress syndrome
- Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
- Renal failure (kidney dysfunction)
- Respiratory failure (inadequate gas exchange by the respiratory system)
- Bradycardia (abnormally slow heart action)
- Chest pain
- Coagulopathy (blood's ability to clot is impaired)
- Coronary artery stenosis (narrowing of coronary artery)
- Dizziness (excl vertigo)
- Dyspnoea (difficult or laboured respiration)
What are the existing conditions these people have? *
- High Blood Cholesterol: 5 people, 17.86%
- Pain: 4 people, 14.29%
- Ill-Defined Disorder: 4 people, 14.29%
- Sleep Disorder: 3 people, 10.71%
- Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 10.71%
- Depression: 3 people, 10.71%
- Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 2 people, 7.14%
- Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 2 people, 7.14%
- Neuropathy Peripheral (surface nerve damage): 2 people, 7.14%
- Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 7.14%
* Approximation only. Some reports may have incomplete information.
Do you take Plendil and Clonazepam?
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Related studies:
Effectiveness of, side effects of, and alternative drugs to the 2 drugs:
- Plendil (4,990 reports)
- Clonazepam (146,272 reports)
Browse all drug interactions of Plendil and Clonazepam:
a b c d e f g h i j k l m n o p q r s t u v w x y zSub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Browse all side effects of Plendil:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Clonazepam:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Plendil and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Clonazepam and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zRelated publications that referenced our studies
- McFarlane SI, "Torsades de Pointes induced by Methadone and Clonazepam Use", , 2015 Jan .
- Ashkar AG, Goldberg T, Maraj I, Masters A, McFarlane SI, "Torsades De Pointes Induced by Methadone and Clonazepam Use", International Journal of Medical and Pharmaceutical Case Reports, 2015 Jan .
- McFarlane, S. I. , "Torsades de Pointes induced by Methadone and Clonazepam Use", , 2014 Jan .
- McFarlane SI, "Torsades de Pointes induced by Methadone and Clonazepam Use", , 2015 Jan .
- Ashkar AG, Goldberg T, Maraj I, Masters A, McFarlane SI, "Torsades De Pointes Induced by Methadone and Clonazepam Use", International Journal of Medical and Pharmaceutical Case Reports, 2015 Jan .
- McFarlane, S. I. , "Torsades de Pointes induced by Methadone and Clonazepam Use", , 2014 Jan .
How the study uses the data?
The study uses data from the FDA. It is based on felodipine and clonazepam (the active ingredients of Plendil and Clonazepam, respectively), and Plendil and Clonazepam (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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