Pralatrexate and Methotrexate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Pralatrexate (pralatrexate) and Methotrexate (methotrexate sodium). Common drug interactions include postictal state among females and staphylococcal bacteraemia among males.

The phase IV clinical study analyzes what interactions people have when they take Pralatrexate and Methotrexate. It is created by eHealthMe based on reports of 27 people who take the same drugs from the FDA, and is updated regularly.

What is Pralatrexate?

Pralatrexate has active ingredients of pralatrexate. eHealthMe is studying from 231 Pralatrexate users. Check the latest studies of Pralatrexate.

What is Methotrexate?

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 604,312 Methotrexate users. Check the latest studies of Methotrexate.

On Jul, 14, 2026

27 people who take Pralatrexate and Methotrexate together, and have interactions are studied.

Pralatrexate and Methotrexate drug interactions.

What are the common drug interactions of Pralatrexate and Methotrexate, by gender? *:

female:

Postictal state
Metastases to central nervous system (cancer spreads to central nervous system)
Malignant neoplasm progression (cancer tumour came back)
Metastases to meninges (cancer spreads to meninges)
Neoplasm progression (growth of tumour)
Drug intolerance (drug sensitivity)
Disease progression
Hepatosplenic t-cell lymphoma (neoplasm comprising medium-sized cytotoxic t-cells that show a significant sinusoidal infiltration in the liver, spleen, and bone marrow)
Pyrexia (fever)
Drug ineffective

male:

Staphylococcal bacteraemia (a bacterial infection of blood)
Drug ineffective
Pseudomonas infection (pseudomonas infection is caused by a bacterium, pseudomonas aeruginosa)
Staphylococcal sepsis (blood infection by an infection with staphylococcus bacteria)

What are the common drug interactions of Pralatrexate and Methotrexate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Drug ineffective
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters)
Progressive multifocal leukoencephalopathy (rapidly progressive neuromuscular disease caused by opportunistic infection of brain cells)
Pseudomonas infection (pseudomonas infection is caused by a bacterium, pseudomonas aeruginosa)

40-49:

Paralysis
Spinal cord compression
Postictal state
Metastases to central nervous system (cancer spreads to central nervous system)
Malignant neoplasm progression (cancer tumour came back)
Metastases to meninges (cancer spreads to meninges)
Neoplasm progression (growth of tumour)
Disease progression
Drug intolerance (drug sensitivity)
Hepatosplenic t-cell lymphoma (neoplasm comprising medium-sized cytotoxic t-cells that show a significant sinusoidal infiltration in the liver, spleen, and bone marrow)

50-59:

Staphylococcal bacteraemia (a bacterial infection of blood)
Staphylococcal sepsis (blood infection by an infection with staphylococcus bacteria)

60+:

Fatigue (feeling of tiredness)
Malaise (a feeling of general discomfort or uneasiness)
Photosensitivity reaction
Pyrexia (fever)

What are the existing conditions these people have? *

Hepatosplenic T-Cell Lymphoma (neoplasm comprising medium-sized cytotoxic t-cells that show a significant sinusoidal infiltration in the liver, spleen, and bone marrow): 9 people, 33.33%
T-Cell Lymphoma (a blood cell cancer): 2 people, 7.41%
Mycosis Fungoides (lymphocytes (a type of white blood cell) become malignant (cancerous) and affect the skin): 2 people, 7.41%
Large Granular Lymphocytosis (increased number of large granular white blood cells): 2 people, 7.41%
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters): 2 people, 7.41%
Anaplastic Large Cell Lymphoma T- And Null-Cell Types Stage Iv (t-cell or null-cell cancer, a type of blood cancer stage iv): 2 people, 7.41%

* Approximation only. Some reports may have incomplete information.

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