Praluent and Juxtapid drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Praluent (alirocumab) and Juxtapid (lomitapide mesylate). Common drug interactions include hepatic enzyme increased among females and cerebrovascular accident among males.

The phase IV clinical study analyzes what interactions people have when they take Praluent and Juxtapid. It is created by eHealthMe based on reports of 78 people who take the same drugs from the FDA, and is updated regularly.

What is Praluent?

Praluent has active ingredients of alirocumab. It is often used in high blood cholesterol. eHealthMe is studying from 24,963 Praluent users. Check the latest studies of Praluent.

What is Juxtapid?

Juxtapid has active ingredients of lomitapide mesylate. eHealthMe is studying from 4,279 Juxtapid users. Check the latest studies of Juxtapid.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

78 people who take Praluent and Juxtapid together, and have interactions are studied.

Praluent and Juxtapid drug interactions.

What are the common drug interactions of Praluent and Juxtapid, by gender? *:

female:

Hepatic enzyme increased
Diarrhoea
Acute pulmonary oedema (sudden deposit of fluid in the lung))
Acute respiratory failure
Cardiac arrest
Faeces discoloured
Fatigue (feeling of tiredness)
Haematochezia (passage of stools containing blood)
Large intestinal haemorrhage (bleeding in large intestine)
Alanine aminotransferase increased

male:

Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Drug ineffective
Nausea (feeling of having an urge to vomit)
Vomiting
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Diarrhoea
Abdominal pain
Abdominal discomfort
Low density lipoprotein decreased (cholesterol decreased)
Fatigue (feeling of tiredness)

What are the common drug interactions of Praluent and Juxtapid, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Drug ineffective
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Diarrhoea
Bowel movement irregularity
Flatulence (flatus expelled through the anus)
Infrequent bowel movements
Micturition urgency (urgency to pass the urine)
Motion sickness (travel sickness)
Nasopharyngitis (inflammation of the nasopharynx)

40-49:

Liver disorder (liver diseases)

50-59:

Hepatic enzyme increased
Back pain
Alanine aminotransferase increased
Aspartate aminotransferase increased
Abdominal discomfort
Diarrhoea
Neck pain
Syncope (loss of consciousness with an inability to maintain postural tone)
Angina pectoris (chest pain due to ischemia of the heart muscle)
Angina unstable (chest pain due to ischemia of the heart muscle- unstable)

60+:

Diarrhoea
Fatigue (feeling of tiredness)
Peripheral vascular disorder
Pneumonia
Alanine aminotransferase increased
Aspartate aminotransferase increased
Contusion (a type of hematoma of tissue in which capillaries)
Dizziness
Drug administration error
Fall

What are the existing conditions these people have? *

Low Density Lipoprotein: 28 people, 35.90%
Low Density Lipoprotein Abnormal (cholesterol abnormal): 12 people, 15.38%
Hyperlipidaemia (presence of excess lipids in the blood): 7 people, 8.97%
Depression: 6 people, 7.69%
Stable Angina (a constant chest pain): 4 people, 5.13%
Iron Deficiency Anaemia: 4 people, 5.13%
High Blood Pressure: 4 people, 5.13%

* Approximation only. Some reports may have incomplete information.

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