Praluent and Vitamin d3 drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Praluent (alirocumab) and Vitamin d3 (cholecalciferol). Common drug interactions include trismus among females and injection site haemorrhage among males.

The phase IV clinical study analyzes what interactions people have when they take Praluent and Vitamin d3. It is created by eHealthMe based on reports of 50 people who take the same drugs from the FDA, and is updated regularly.

What is Praluent?

Praluent has active ingredients of alirocumab. It is often used in high blood cholesterol. eHealthMe is studying from 24,963 Praluent users. Check the latest studies of Praluent.

What is Vitamin d3?

Vitamin d3 has active ingredients of cholecalciferol. It is often used in heart health. eHealthMe is studying from 32,172 Vitamin d3 users. Check the latest studies of Vitamin d3.



On Aug, 11, 2026

50 people who take Praluent and Vitamin d3 together, and have interactions are studied.

Praluent and Vitamin d3 drug interactions.

What are the common drug interactions of Praluent and Vitamin D3, by gender? *:

female:

  1. Trismus (reduced opening of the jaws)
  2. Abdominal pain
  3. Anaphylactic reaction (serious allergic reaction)
  4. Balance disorder
  5. Blood pressure increased
  6. Blood sodium decreased
  7. Bone pain
  8. Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
  9. Cataract (clouding of the lens inside the eye)
  10. Confusional state

male:

  1. Injection site haemorrhage (bleeding from injection site)
  2. Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
  3. Sinus disorder (disease of sinus)
  4. Visual impairment
  5. Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
  6. Arterial occlusive disease (slow process through which arteries throughout the body become progressively narrowed and eventually completely blocked)
  7. Arthralgia (joint pain)
  8. Blood creatinine increased
  9. Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
  10. Communication disorder (speech and language disorder)

What are the common drug interactions of Praluent and Vitamin D3, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

  1. Panic attack
  2. Salivary hypersecretion (excess saliva secretion)
  3. Stent placement
  4. Therapeutic response unexpected
  5. Vomiting

50-59:

  1. Muscle spasms (muscle contraction)
  2. Injection site reaction
  3. Headache (pain in head)
  4. Hypotension (abnormally low blood pressure)
  5. Insomnia (sleeplessness)
  6. Malaise (a feeling of general discomfort or uneasiness)
  7. Spinal pain (pain in spine)
  8. Syncope (loss of consciousness with an inability to maintain postural tone)
  9. Tooth extraction

60+:

  1. Injection site haemorrhage (bleeding from injection site)
  2. Pain
  3. Influenza
  4. Lymphocyte count decreased
  5. Mean cell volume increased (more than normal average red blood cell volume)
  6. Nodule (a growth of abnormal tissue)
  7. Protein total decreased
  8. Psoriasis (immune-mediated disease that affects the skin)
  9. Red blood cell count decreased
  10. Rhinorrhoea (watery mucus discharge from the nose)

What are the existing conditions these people have? *

  1. Hyperlipidaemia (presence of excess lipids in the blood): 13 people, 26.00%
  2. Pain: 4 people, 8.00%
  3. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 8.00%
  4. High Blood Pressure: 3 people, 6.00%

* Approximation only. Some reports may have incomplete information.

Do you take Praluent and Vitamin d3?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Praluent and Vitamin d3:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Praluent:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Vitamin d3:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Praluent and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Vitamin d3 and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on alirocumab and cholecalciferol (the active ingredients of Praluent and Vitamin d3, respectively), and Praluent and Vitamin d3 (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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