Prednisolone and Dactinomycin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Prednisolone (prednisolone) and Dactinomycin (dactinomycin). Common drug interactions include febrile bone marrow aplasia among females and osteoporosis among males.

The phase IV clinical study analyzes what interactions people have when they take Prednisolone and Dactinomycin. It is created by eHealthMe based on reports of 35 people who take the same drugs from the FDA, and is updated regularly.

What is Prednisolone?

Prednisolone has active ingredients of prednisolone. It is often used in rheumatoid arthritis. eHealthMe is studying from 212,675 Prednisolone users. Check the latest studies of Prednisolone.

What is Dactinomycin?

Dactinomycin has active ingredients of dactinomycin. eHealthMe is studying from 2,577 Dactinomycin users. Check the latest studies of Dactinomycin.

On Jul, 14, 2026

35 people who take Prednisolone and Dactinomycin together, and have interactions are studied.

Prednisolone and Dactinomycin drug interactions.

What are the common drug interactions of Prednisolone and Dactinomycin, by gender? *:

female:

Febrile bone marrow aplasia (bone marrow greatly decreases or stops production of blood cells)
Febrile neutropenia (fever with reduced white blood cells)
Mucosal inflammation (infection of mucous membrane)
Weight decreased
Vomiting
Disseminated intravascular coagulation (systemic activation of blood coagulation)
Hepatic encephalopathy (spectrum of neuropsychiatric abnormalities in patients with liver failure)
Hepatic failure (liver failure)
Hepatic necrosis (large portions of liver die off due to severe liver disease)
Hepatitis acute

male:

Osteoporosis (bones weak and more likely to break)
Constipation
Febrile neutropenia (fever with reduced white blood cells)
Hypogammaglobulinaemia (an abnormally low concentration of gamma globulin in the blood and increased risk of infection)
Hypogonadism (reduction or absence of hormone secretion or other physiological activity of the gonads (testes or ovaries))
Lower respiratory tract infection
Mucosal inflammation (infection of mucous membrane)
Nausea (feeling of having an urge to vomit)
Primary hypothyroidism (failure of the thyroid gland to produce or release thyroid hormones into the bloodstream)
Pruritus (severe itching of the skin)

What are the common drug interactions of Prednisolone and Dactinomycin, by age (0-1 to 60+)? *:

0-1:

Death
Drug ineffective
Haemorrhage intracranial (bleeding within the skull)
Hospitalisation
Neoplasm progression (growth of tumour)
Pneumocystis jiroveci pneumonia (fungal infection of the lungs)
Pyrexia (fever)
Respiratory failure (inadequate gas exchange by the respiratory system)
Thrombocytopenia (decrease of platelets in blood)
Vomiting

2-9:

Growth hormone deficiency
Sinusitis (inflammation of sinus)

10-19:

Febrile bone marrow aplasia (bone marrow greatly decreases or stops production of blood cells)
Febrile neutropenia (fever with reduced white blood cells)
Mucosal inflammation (infection of mucous membrane)
Weight decreased
Vomiting
Acute graft versus host disease in skin (acute complication on skin following an allogeneic tissue/blood transplant)
Disease recurrence
Infection
Bladder dysfunction
Cytomegalovirus infection

20-29:

Osteonecrosis (death of bone)

30-39:

Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)
Osteonecrosis (death of bone)

40-49:

Disseminated intravascular coagulation (systemic activation of blood coagulation)
Hepatic encephalopathy (spectrum of neuropsychiatric abnormalities in patients with liver failure)
Hepatic failure (liver failure)
Hepatic necrosis (large portions of liver die off due to severe liver disease)
Hepatitis acute
Hepatitis cholestatic (flow of bile from the liver is slowed or blocked)
Hypotension (abnormally low blood pressure)
Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)
Thrombocytopenia (decrease of platelets in blood)

50-59:

Pruritus (severe itching of the skin)
Pyrexia (fever)
Rash
Rectal lesion
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Bronchopulmonary aspergillosis (lung disorder caused by aspergillus fungi)
Febrile neutropenia (fever with reduced white blood cells)
Hypogammaglobulinaemia (an abnormally low concentration of gamma globulin in the blood and increased risk of infection)
Lower respiratory tract infection
Mucosal inflammation (infection of mucous membrane)

60+:

Anaemia (lack of blood)
Ewing's sarcoma (malignant small, round, blue cell tumour)
Pneumonia

What are the existing conditions these people have? *

Sarcoma Metastatic (rare cancers that develop in the muscle, bone, nerves, cartilage, tendons, blood vessels and the fatty and fibrous tissues spreads to other parts): 7 people, 20.00%
Ewing's Sarcoma (malignant small, round, blue cell tumour): 4 people, 11.43%
Non-Hodgkin's Lymphoma (malignant (cancer) cells form in the lymph system): 3 people, 8.57%
Rhabdomyosarcoma (cancer of the bone, soft tissues, or connective tissue (e.g., tendon or cartilage)): 2 people, 5.71%
Haemangioma-Thrombocytopenia Syndrome (vascular tumour leads to decreased platelet counts and sometimes other bleeding problems): 2 people, 5.71%
Gestational Trophoblastic Disease (disease of foetus surrounding during pregnancy): 2 people, 5.71%

* Approximation only. Some reports may have incomplete information.

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